Most Viewed Articles
Drug nanotargeting for treatment of neurodegeneration and aging
Joseph S. D'Arrigo
Published: Tuesday, June 29, 2021
Viewed: 84610
The potential of GHK as an anti-aging peptide
Warren Ladiges, Yan Dou, Amanda Lee, Lida Zhu, John Morton
Published: Friday, March 27, 2020
Viewed: 16487
Irreversible effects of anticholinergic withdrawal in the elderly: a case report
Charisse Chehovich, Claudia Lee, Tammie Lee Demler
Published: Tuesday, June 29, 2021
Viewed: 10785
Sleep-deprived cognitive impairment in aging mice is alleviated by rapamycin
Warren Ladiges, Kishore Mukherjee, Amanda Lee, Lida Zhu, Martin Darvas
Published: Monday, December 30, 2019
Viewed: 8831
Resilience in aging and age-related disease. Abstracts from the 2019 Barshop Conference on Aging
Warren Ladiges, Yuji Ikeno, Liang Wang
Published: Friday, March 27, 2020
Viewed: 8618
The rationale for testing drug combinations in aging intervention studies
Kavita C Sharma, Juan Wang, Zhou Jiang, Jenna Klug, Martin Darvas, Denise M Imai, Timothy Snider, Laura Niedernhofer, Warren C Ladiges
Published: Monday, December 30, 2019
Viewed: 8491
Novel LMNA mutations in Greek and Myanmar Patients with Progeroid Features and Cardiac Manifestations
Junko Oshima, Renuka Kandhaya-Pillai, Fuki M Hisama, Stephanie A Bucks, Soe Yarzar, Haroula Korovou, George M Martin
Published: Monday, June 29, 2020
Viewed: 8380
Highly expressed ribosomal protein L34 predicts poor prognosis in acute myeloid leukemia and could be a potential therapy target
Liang Wang, Jing Yang, Henan Wang, Weida Wang, Xiaojie Liang
Published: Friday, March 27, 2020
Viewed: 7870
Development of a Geropathology Grading Platform for nonhuman primates
Warren Ladiges, Katie J Olstad, Denise M Imai, Rebekah I Keesler, Rachel Reader, John H Morrison, Jeffery A Roberts, John P Capitanio, Elizabeth S Didier, Marcelo J Kuroda, Heather Simmons, Shabnam Salimi, Julie A Mattison, Yuji Ikeno
Published: Friday, March 27, 2020
Viewed: 7859
LINC00271 inhibits epithelial-mesenchymal transition of papillary thyroid cancer cells by downregulating trefoil factor 3 expression
Jianda Dong, Pihong Li, Xiaoyu Pan, Zhouci Zheng, Yihan Sun, Yifan Han
Published: Monday, June 29, 2020
Viewed: 7640
The CB6F1 mouse is a model for studying cognition and brain morphometry with increasing age
Warren Ladiges, Davika Gandhay, Christina Pettan Brewer
Published: Wednesday, March 29, 2023
Viewed: 7637
QuPath. A new digital imaging tool for geropathology
Warren Ladiges, Amanda Lee, Zhou Jiang, Lida Zhu
Published: Monday, June 29, 2020
Viewed: 7631
Thioredoxin overexpression in mitochondria showed minimum effects on aging and age-related diseases in male C57BL/6 mice
Madeline G. Roman, Lisa C. Flores, Geneva M. Cunningham, Christie Cheng, Sara Dube, Colton Allen, Holly Van Remmen, Yidong Bai, Thomas L. Saunders, Yuji Ikeno
Published: Friday, March 27, 2020
Viewed: 7628
Aging pet cats develop neuropathology similar to human Alzheimer’s disease
Warren Ladiges, Jenna Klug, Jessica M. Snyder, Martin Darvas, Denise M. Imai, Molly Church, Caitlin Latimer, C . Dirk Keene
Published: Tuesday, September 29, 2020
Viewed: 7116
Drug-Induced Hemolytic Crisis During Ibrutinib plus Venetoclax for the Treatment of Mantle-Cell Lymphoma: A Rare Hematologic Adverse Reaction
Xin Wen, Liang Wang, Yingzhi He, Shan Wang
Published: Monday, December 30, 2019
Viewed: 7061
Interfering with miR-24 alleviates rotenone-induced dopaminergic neuron injury via enhancing autophagy by upregulating DJ-1
Fengrui Li, Biao Ge, Hairong Wu, Dan Shao, Shulin Li
Published: Monday, December 30, 2019
Viewed: 7049
Down-regulation of miR-181a promotes microglial M1 polarization through increasing expression of NDRG2
Bo Zhou, Yali Niu, Chunxiao Wan, Rui wu, Heying Sun, Danqing Lu
Published: Friday, March 27, 2020
Viewed: 6928
Thioredoxin and aging: What have we learned from the survival studies?
Lisa C. Flores, Madeline G. Roman, Geneva M. Cunningham, Christie Cheng, Colton Allen, Gene Borden Hubbard, Yidong Bai, Thomas L. Saunders, Yuji Ikeno
Published: Tuesday, September 29, 2020
Viewed: 6901
Sex-dependent lifespan extension of ApcMin/+ FAP mice by chronic mTOR inhibition
Manish Parihar, Sherry G Dodds, Marty Javors, Randy Strong, Paul Hasty, Zelton Dave Sharp
Published: Thursday, December 31, 2020
Viewed: 6814
MicroRNA-152 suppresses cell proliferation and tumor growth of bladder cancer by targeting KLF5 and MKK7
Liangliang Wang, Yu Hui, Yuhua Huang, Xiang Ding
Published: Monday, December 30, 2019
Viewed: 6794
Progress in drug treatment of elderly chronic heart failure
Feng Liu, Siting Zhang
Published: Thursday, December 31, 2020
Viewed: 6762
Mitochondrial-targeted methionine sulfoxide reductase overexpression increases the production of oxidative stress in mitochondria from skeletal muscle
Adam B. Salmon, Arunabh Bhattacharya, Daniel Pulliam, Yuhong Liu
Published: Friday, March 27, 2020
Viewed: 6654
Time for an Alzheimer’s disease cocktail
Warren Carl Ladiges
Published: Friday, March 27, 2020
Viewed: 6596
A model for studying cutaneous wound healing and resilience to aging: Ear punch biopsy in old mice
Warren Ladiges, Zhou Jiang, Jessie Chen, Juan Wang, Ruby Mangalindan, Lida Zhu
Published: Tuesday, September 29, 2020
Viewed: 6506
A mouse model of sleep deprived neuropathology to study resilience to Alzheimer’s disease
Warren Ladiges, Yan Dou, Jinzi Wu, Lida Zhu, Martin Darvas
Published: Monday, June 29, 2020
Viewed: 6470
Pioglitazone up-regulates MALAT1 and promotes the proliferation of endothelial progenitor cells through increasing c-Myc expression in type 2 diabetes mellitus
Xiaoxu Yang, Chen Hu, Yan Sun
Published: Friday, March 27, 2020
Viewed: 6398
Resilience to aging is a heterogeneous characteristic defined by physical stressors
Haoyi Lei, Derek M. Huffman, Adam B. Salmon, Nathan K. LeBrasseur, Christy Carter, Arlan Richardson, Steve Austad, Warren Ladiges
Published: Wednesday, March 30, 2022
Viewed: 6302
Resilience to acute sleep deprivation is associated with attenuation of hippocampal mediated learning impairment
Warren Ladiges, Amanda Lee, Haoyi Lei, Lida Zhu, Zhou Jiang
Published: Thursday, December 31, 2020
Viewed: 6173
IL-17 regulates the expression of major histocompatibility complex II and VEGF in DLBCL mice on tumor growth
Xin Xu, Ting Wei, Weijie Zhong, Zhigang Zhu, Feng Liu, Qingshan Li
Published: Monday, June 29, 2020
Viewed: 6155
Gastrointestinal Disasters of Cetuximab in the Treatment of Metastatic Colorectal Cancer: Mechanism and its Effect on Prognosis
Junfeng Sun, Yue Wu, Haowei Jia, Xinqi Bao, Tianyu Zhu, Ruixin Li, Hongchao Zhao
Published: Monday, June 29, 2020
Viewed: 6118
The cellular senescence unification model and telomerase therapy: To treat all age-related diseases
Steve Liebich
Published: Tuesday, September 29, 2020
Viewed: 6116
Guidelines for the Prevention of Coronavirus Pneumonia in Elderly People
Wei Ma, Jun Zhao, Gang Xu, Congrui Feng, Yuluo Chen, Feng Liu
Published: Monday, June 29, 2020
Viewed: 6108
Physical performance is enhanced in old mice fed a short term diet medicated with rapamycin, acarbose, and phenylbutyrate
Warren Ladiges, Megan Ellis, Zhou Jiang
Published: Monday, March 29, 2021
Viewed: 6035
An immune stress test for resilience to aging: Pneumococcal vaccine response
Warren Ladiges, Ryan Oveson, Zhou Jiang, Michali Izhak, Kavita Sharma
Published: Tuesday, September 29, 2020
Viewed: 5919
Finding prodromal frailty in a community-dwelling healthy older cohort by survey of BDNF or hand grip strength classified by BMI
Mitsugu Hachisu, Masahiro Hashizume, Hisashi Kawai, Motonaga Kojima, Yoshinori Fujiwara, Shuichi Obuchi, Mari Kogo, Masayuki Ohbayashi, Noriko Koyama, Miki Takenaka, Kazushige Ihara
Published: Tuesday, September 29, 2020
Viewed: 5874
Eosinophilic crystalline pneumonia, an age-related lesion in mice
Jenna J Klug, Jessica M Snyder
Published: Thursday, December 31, 2020
Viewed: 5805
Leucine metabolite β-hydroxy-β-methyl butyrate (HMB) supplementation on muscle mass during resistance training in older subjects: meta-analysis
Guangqin Zou, Quan Wang, Hua Wan, Xiang Lu, Wei Gao
Published: Wednesday, March 30, 2022
Viewed: 5762
Oxidative stress in aging: stayin’ alive?
Lisa C. Flores, Yuji Ikeno
Published: Monday, June 29, 2020
Viewed: 5728
Anti-tumor effect of pcDNA3.1(-)/rMETase-shUCA1 hyaluronic acid-modified G5 polyamidoamine nanoparticles on gastric cancer
Chunying Xie, Zhenxing Huang, Zhaohui Huang, Yanyan Guo, Xue Zhang
Published: Monday, June 29, 2020
Viewed: 5685
Short-term oral rapamycin prevents age-related learning impairment in mice
Warren Ladiges, Haoyi Lei, Juan Wang, Zhou Jiang
Published: Tuesday, September 29, 2020
Viewed: 5659
Thioredoxin down-regulation in the cytosol in thioredoxin 2 transgenic mice did not have beneficial effects to extend lifespan in male C57BL/6 mice
Lisa C. Flores, Madeline G. Roman, Geneva M. Cunningham, Christie Cheng, Colton Allen, Yidong Bai, Gene B. Hubbard, Yuji Ikeno
Published: Thursday, December 31, 2020
Viewed: 5655
The potential of XPO1 inhibitors as a game changer in relapsed/refractory hematologic malignancies
Henan Wang, Liang Wang, Jing Yang
Published: Monday, June 29, 2020
Viewed: 5647
Gam-COVID-Vac (Sputnik V): a heterologous adenoviral vector-based COVID-19 vaccine
Shyh Poh Teo, Sanny Zi Lung Choo
Published: Tuesday, June 29, 2021
Viewed: 5643
Myocardial Cell Aging in the Elderly
Feng Liu, Wenxi Li
Published: Tuesday, September 29, 2020
Viewed: 5545
Long-term treatment with Elamipretide enhances healthy aging phenotypes in mice
Kaitlin Nickel, Lida Zhu, Ruby Mangalindan, Jessica M. Snyder, Jeremy Whitson, Maryia Sweetwyne, Ana P. Valencia, Jenna Klug, Zhou Jiang, David J. Marcinek, Peter Rabinovitch, Warren Ladiges, Matthew Tucker
Published: Friday, September 30, 2022
Viewed: 5538
Microbiome in aging of Gut and Brain (MiaGB): paving the ways to understand gut-brain axis in aging
Michal M. Masternak, Hariom Yadav
Published: Wednesday, March 30, 2022
Viewed: 5528
Di-2-pyridylketone 4, 4-dimethyl-3-thiosemicarbazone effectively induces human colorectal carcinoma cell apoptosis via mTOR pathway
Qianqian Fu, Shengli Wang, Chuyun Zhu, Zhenlong Zhou, Xiaojuan Yu, Yong Zhang
Published: Thursday, September 30, 2021
Viewed: 5512
Spontaneous chordoma: a case report on a female UM-HET3 mouse from the SLAM study
Eleonora Duregon, Rafael de Cabo, Camila Vieira Ligo Teixeira, Dushani L. Palliyaguru, Annamaria L. Rudderow, Victoria Hoffmann, Michel Bernier, Nathan L. Price, Simonetta Camandola
Published: Thursday, December 31, 2020
Viewed: 5473
A geropathology approach for identifying therapeutic targets to prevent pathological complications of COVID-19
Warren Ladiges, Yuji Ikeno, Liang Wang, Feng Liu
Published: Monday, June 29, 2020
Viewed: 5429
miR-181c inhibits prostatic epithelial cell proliferation caused by chronic non-bacterial prostatitis through down-regulating COX-2
Xiang Ding, Xu Xu, Yuhua Huang, Jianquan Hou, Jinxing Lv
Published: Thursday, December 31, 2020
Viewed: 5393
Neutrophil response to cyclophosphamide predicts resilience to age-related learning impairment
Lida Zhu, Warren Ladiges, Katie Nickel, Marianne Bjorner
Published: Thursday, December 31, 2020
Viewed: 5356
Geropathology. An inside view of biological aging
Warren Ladiges
Published: Wednesday, March 30, 2022
Viewed: 5304
Application and research progress of BCL2 inhibitors in elderly patients with hematologic malignancies
Liang Wang, Yufan Wang
Published: Thursday, December 31, 2020
Viewed: 5255
KDClassifier: A urinary proteomic spectra analysis tool based on machine learning for the classification of kidney diseases
Wanjun Zhao, Yong Zhang, Xinming Li, Yonghong Mao, Changwei Wu, Lijun Zhao, Fang Liu, Jingqiang Zhu, Jingqiu Cheng, Hao Yang, Guisen Li
Published: Thursday, September 30, 2021
Viewed: 5253
Recent advances in the genetic association between osteoporotic fracture and sarcopenia
Qiaocong Chen, Huiling Lou, Cheng Peng
Published: Monday, March 29, 2021
Viewed: 5152
Coronary artery stenosis regression by long-term standard dose statin therapy in middle-aged and elderly patients: Report and analysis of 31 cases
Feng Liu, Zhilei Ren, Chongzhe Yang, Kaihua Huang
Published: Tuesday, September 29, 2020
Viewed: 5119
PathoClock and PhysioClock in mice recapitulate human multimorbidity and heterogeneous aging
Warren Ladiges, Shabnam Salimi, Christina Pettan-Brewer
Published: Friday, December 31, 2021
Viewed: 5092
Hepatic steatosis, a lesion reported in captive aged common marmosets
Sebastian Eduardo Carrasco, Olga Lucia Franco-Mahecha
Published: Monday, March 29, 2021
Viewed: 5066
Denosumab for the treatment of osteoporosis
Shyh Poh Teo
Published: Tuesday, September 29, 2020
Viewed: 5033
Progress on the study of fibroblast growth factors as novel therapeutics in post-stroke cognitive impairment
Hong Fan, Mengqi Li
Published: Thursday, September 30, 2021
Viewed: 5033
Association of anemia with rehabilitation outcome for subacute geriatric rehabilitation patients in a secondary hospital in malaysia
Mann Leon Chin, Christopher WS Chan, Huey Ee Chong, Wee Kooi Cheah
Published: Friday, December 31, 2021
Viewed: 5033
Safety and efficacy of the Novavax vaccine—a narrative review
Shyh Poh Teo, Sanny Zi Lung Choo
Published: Friday, December 31, 2021
Viewed: 5023
Castleman disease with rapidly progressive pemphigus: case report
Liang Wang, Ruiying Fu, Yingzhi He
Published: Thursday, December 31, 2020
Viewed: 4967
The unrecognized potential of pet cats for studying aging and age-related diseases
Warren Ladiges
Published: Friday, December 31, 2021
Viewed: 4947
Optimal induction treatment regimens for extranodal NK/T-cell lymphoma: lessons learned, challenges, and proposals
Liang Wang, Jing Yang, Ruiying Fu, Xindi Liu, Liqiang Wei
Published: Thursday, December 31, 2020
Viewed: 4864
Arthritis as an adverse event of special interest post COVID-19 vaccine implementation
Shyh Poh Teo
Published: Monday, March 29, 2021
Viewed: 4850
Chimeric antigen receptor T cell therapy in cancer: Advances and challenges
Yuanzheng Liang, Liang Wang
Published: Thursday, September 30, 2021
Viewed: 4819
Advances in targeting programmed cell death 1/programmed cell death-ligand 1 therapy for hematological malignancies
Liang Wang, Yuanzheng Liang, Wanying Zhao
Published: Friday, December 31, 2021
Viewed: 4806
Nasal type extranodal natural killer/T-cell lymphoma-associated hemophagocytic lymphohistiocytosis: a Case report and literature review
Xuelin Liu, Liqiang Wei, Jing Yang, Jin Ye, Liang Wang
Published: Wednesday, March 30, 2022
Viewed: 4778
Immunotherapy: the blockbuster in cancer treatment
Liang Wang
Published: Tuesday, September 29, 2020
Viewed: 4775
The critical role of macrophages in ovarian cancer treatment
Yiran Wang, Mingyi Wang
Published: Friday, September 30, 2022
Viewed: 4658
Precision aging. Human lifespan has intrinsic limits but measurable outcomes
Warren Ladiges
Published: Tuesday, June 29, 2021
Viewed: 4656
Preventive effect of rehabilitation training therapy on muscle quality in patients with stroke: A retrospective study
Xiang Lu, Dandan Feng, Wei Gao, Can Zhao, Dan Chen, Xiaojing He
Published: Friday, December 31, 2021
Viewed: 4650
A fornix infarction causing post-operative anterograde amnesia
Shyh Poh Teo
Published: Tuesday, June 29, 2021
Viewed: 4648
The antidiabetic drug acarbose suppresses age-related lesions in C57BL/6 mice in an organ dependent manner
Zhou Jiang, Sneh Gupta, Warren Ladiges
Published: Tuesday, June 29, 2021
Viewed: 4582
The aging immune system. Abstracts presented at the Masoro-Barshop conference on aging, October 13-15, 2021
Warren Ladiges
Published: Friday, December 31, 2021
Viewed: 4514
Molecular hydrogen may activate the transcription factor Nrf2 to alleviate oxidative stress through the hydrogen-targeted porphyrin
Shigeo Ohta
Published: Tuesday, May 23, 2023
Viewed: 4511
Molecular hydrogen may activate the transcription factor Nrf2 to alleviate oxidative stress through the hydrogen-targeted porphyrin
Shigeo Ohta
Published: Tuesday, May 23, 2023
Viewed: 4511
Cardiac arrest in an older male patient treated with flecainide for atrial fibrillation
Tiziana Ciarambino, Rosario Bottone, Gennaro Sansone, Mauro Giordano
Published: Tuesday, June 29, 2021
Viewed: 4488
Thioredoxin – a magic bullet or a double-edged sword for mammalian aging?
Yuji Ikeno
Published: Tuesday, June 29, 2021
Viewed: 4475
2020 Reviewer Acknowledgment
Editorial Office of Aging Pathobiology and Therapeutics
Published: Thursday, December 31, 2020
Viewed: 4473
Mouse modeling for anxiety disorders in older adults
Martin Darvas, Warren Ladiges, Nadia Postupna
Published: Thursday, September 30, 2021
Viewed: 4422
The potential of astaxanthin as a natural compound for decelerating skin aging: an update review
Teresa Liliana Wargasetia, Ratna Sariharyanti, Hana Ratnawati
Published: Thursday, December 26, 2024
Viewed: 4398
Older female relatives of Covid-19 patients have an un-satisfactory perception of emergency room performance by clinical staff
Tiziana Ciarambino, Luigia Palmiero, Rosario Bottone, Federico Schettini, Luigi Elio Adinolfi, Mauro Giordano
Published: Tuesday, June 29, 2021
Viewed: 4318
Age effect on mesenchymal stem cell properties: A concise review
Tsz Kin Ng, Chong-Bo Chen, Xin Bin, Yuqiang Huang, Herman S. Cheung
Published: Tuesday, May 23, 2023
Viewed: 4304
Age effect on mesenchymal stem cell properties: A concise review
Tsz Kin Ng, Chong-Bo Chen, Xin Bin, Yuqiang Huang, Herman S. Cheung
Published: Tuesday, May 23, 2023
Viewed: 4304
Clinical diagnosis and treatment of primary small intestinal lymphoma
Guitian Huang
Published: Thursday, September 30, 2021
Viewed: 4257
A mouse model of naturally occurring age-related cognitive impairment
Sara Daneshjoo, Jualiana Moreno, Manuela Rosenfeld, Joo Young Park, Martin Darvas, Warren Ladiges
Published: Friday, September 30, 2022
Viewed: 4241
Pharmaceutical interventions to slow human aging. Are we ready for cocktails?
Warren Ladiges, Manuela Rosenfeld
Published: Thursday, June 30, 2022
Viewed: 4220
Mechanisms of autophagy regulation by adiponectin
Xin Xu, Chan Rong
Published: Friday, December 31, 2021
Viewed: 4195
Evidence for an alternative insulin transporter at the blood-brain barrier
Elizabeth M Rhea, William A Banks, Cassidy Noonan
Published: Tuesday, May 23, 2023
Viewed: 4121
Evidence for an alternative insulin transporter at the blood-brain barrier
Elizabeth M Rhea, William A Banks, Cassidy Noonan
Published: Tuesday, May 23, 2023
Viewed: 4121
Vitiligo as a potential degenerative disease: from oxidative stress to cellular senescence
Yaojun Wang, Jiaoni Chi, Tao Wang, Yue Zhang, Zhimin Li, Jie Chen, Haixia Liu, Qiang Li
Published: Thursday, June 30, 2022
Viewed: 4014
Human microbiota alterations — emerging predictors of renal diseases and kidney-specific aging
Chao Zhao, Miaomiao Pan, Ming Zhang, Xingyu Rong
Published: Wednesday, March 29, 2023
Viewed: 3781
Sarcopenia and falls in older adults
Chieh Chen, Daming Liao
Published: Friday, September 30, 2022
Viewed: 3644
Senescence of mesenchymal stem cells: implications in extracellular vesicles, miRNAs and their functional and therapeutic potentials
Guangqian Zhou, Liangge He, Mingzhu Li, Zhen Liu, Arshad Ahmed Padhiar
Published: Tuesday, October 17, 2023
Viewed: 3606
Sex Matters in Aging. The Canagliflozin Story
Warren Ladiges, Jackson Wezeman
Published: Friday, September 30, 2022
Viewed: 3529
Research progress in the PD-1/PD-L1 pathway and IL-17A in lymphomas
Li Yang, Xin Xu
Published: Thursday, June 30, 2022
Viewed: 3465
On the growth of young neurologists—an interview with Prof. Louis R. Caplan
Qi Qin
Published: Friday, September 30, 2022
Viewed: 3455
Sotrovimab for treatment of COVID-19 infections
Shyh Poh Teo
Published: Thursday, June 30, 2022
Viewed: 3422
Targeting IGF1R signaling for brain aging and Alzheimer’s disease
Warren Ladiges, Joo Young Park, Martin Darvas
Published: Thursday, December 29, 2022
Viewed: 3358
Get back–calorie restriction: Dr. Masoro’s legacy
Yuji Ikeno, Lisa C. Flores
Published: Thursday, June 30, 2022
Viewed: 3318
Targeting metabolism through exercise and nutrition to rejuvenate an aging immune system
Brandt D. Pence
Published: Friday, September 30, 2022
Viewed: 3304
Role of fibro-adipogenic progenitors in skeletal muscle aging
Renwen Wan, Hanli Zhang, Shan Liu, Chunmeng Jiao, Hui Chen, Zhiwen Luo, Xiliang Shang
Published: Wednesday, June 28, 2023
Viewed: 3163
Role of fibro-adipogenic progenitors in skeletal muscle aging
Renwen Wan, Hanli Zhang, Shan Liu, Chunmeng Jiao, Hui Chen, Zhiwen Luo, Xiliang Shang
Published: Wednesday, June 28, 2023
Viewed: 3163
2021 Reviewer Acknowledgment
Editorial Office of Aging Pathobiology and Therapeutics
Published: Friday, December 31, 2021
Viewed: 3130
GHK peptide prevents sleep deprived learning impairment in aging mice
Warren Ladiges, Manuela Rosenfeld, Katie Nickel
Published: Wednesday, March 29, 2023
Viewed: 3129
A reappraisal of the measured concentration of voriconazole based on plasma albumin concentration during its therapeutic drug monitoring
Fangmin Xu, Yexuan Wang, Xiaoshan Zhang, Junhui Yu, Liwen Zhang, Xuben Yu, Haina Zhang
Published: Thursday, June 30, 2022
Viewed: 3121
Influence of metformin on age-related macular degeneration
Albert J Augustin, Jenny Atorf
Published: Tuesday, May 23, 2023
Viewed: 3120
Influence of metformin on age-related macular degeneration
Albert J Augustin, Jenny Atorf
Published: Tuesday, May 23, 2023
Viewed: 3120
On the frontier of immunogerontology—an interview with Prof. Graham Pawelec
Xiaodong Li
Published: Friday, September 30, 2022
Viewed: 3111
Targeted regulation of senescence-associated secretory phenotype with an aptamer-conjugated activatable senomorphic
Yanlan Liu, Yuqi Xie, Jili Li, Pingyu Wu, Linlin Wang, Donghui Hong, Jian Wang
Published: Wednesday, June 28, 2023
Viewed: 3094
Targeted regulation of senescence-associated secretory phenotype with an aptamer-conjugated activatable senomorphic
Yanlan Liu, Yuqi Xie, Jili Li, Pingyu Wu, Linlin Wang, Donghui Hong, Jian Wang
Published: Wednesday, June 28, 2023
Viewed: 3094
On the original aspiration of researching neurodegenerative diseases—an interview with Prof. Jeffrey Kordower
Min Zhu
Published: Thursday, December 29, 2022
Viewed: 3033
Difference in the effectiveness of subthalamic nucleus and globus pallidus deep brain stimulation in Parkinson’s disease
Hushyar Azari
Published: Thursday, June 30, 2022
Viewed: 2991
The Eph receptor A4-mediated demyelination in depression
Quanguang Zhang, Luodan Yang
Published: Thursday, December 29, 2022
Viewed: 2962
On the frontier of chronic obstructive pulmonary disease—an interview with Prof. Peter J Barnes
Wei Ma
Published: Thursday, December 29, 2022
Viewed: 2942
Carvacrol induces osteogenic differentiation of BMSCs and alleviates osteolysis in aged mice by upregulating lncRNA NEAT1 to promote SIRT1 expression
Zefeng Xu, Zeyu Wang, Wenming Ma, Zhihui Huang
Published: Tuesday, December 26, 2023
Viewed: 2932
Additional polgD257A mutation (mutator) does not influence dopaminergic neurodegeneration in aged parkin-deficient mice
Xin-Ran Zhu, David Mrohs, Max Rybarski, Michael Andriske, Pauline Bohne, Melanie D. Mark, Hermann Lübbert
Published: Tuesday, May 23, 2023
Viewed: 2920
Additional polgD257A mutation (mutator) does not influence dopaminergic neurodegeneration in aged parkin-deficient mice
Xin-Ran Zhu, David Mrohs, Max Rybarski, Michael Andriske, Pauline Bohne, Melanie D. Mark, Hermann Lübbert
Published: Tuesday, May 23, 2023
Viewed: 2920
Biological age from a pathological perspective
Warren Ladiges
Published: Wednesday, March 29, 2023
Viewed: 2869
In vitro geroscience. Screening anti-aging drug combinations for neurodegenerative diseases
Warren Ladiges, Soroosh Fatemi, Joo Young Park
Published: Wednesday, June 28, 2023
Viewed: 2829
Cardiovascular aging in patients with chronic kidney disease: pathogenesis and potential therapeutics
Safa Alkhayyat, Mohamed Abdalbary, Zahraa Alhoori
Published: Thursday, September 28, 2023
Viewed: 2829
Cardiovascular aging in patients with chronic kidney disease: pathogenesis and potential therapeutics
Safa Alkhayyat, Mohamed Abdalbary, Zahraa Alhoori
Published: Thursday, September 28, 2023
Viewed: 2829
Is aging “normal”?
Warren Ladiges, Chloe Johnson
Published: Thursday, December 29, 2022
Viewed: 2642
The house cricket is an unrecognized but potentially powerful model for aging intervention studies
Warren Ladiges, Gerald Yu Liao, Manuela Rosenfeld, Jackson Wezeman
Published: Tuesday, March 19, 2024
Viewed: 2614
Role of microRNAs in skin aging and its potential therapeutic interventions
Deusdedit Tusubira, Ashikha Shirin Usman PP, Durairaj Sekar
Published: Tuesday, June 25, 2024
Viewed: 2551
Role of microRNAs in skin aging and its potential therapeutic interventions
Deusdedit Tusubira, Ashikha Shirin Usman PP, Durairaj Sekar
Published: Tuesday, June 25, 2024
Viewed: 2551
The role of immune aging in giant cell arteritis
Patricia Harkins, Sharon Cowley, Robert Harrington, David Kane, Richard Conway
Published: Thursday, September 28, 2023
Viewed: 2499
The role of immune aging in giant cell arteritis
Patricia Harkins, Sharon Cowley, Robert Harrington, David Kane, Richard Conway
Published: Thursday, September 28, 2023
Viewed: 2499
A review of variable risk factors affecting the development of mild cognitive impairment in older adults
Chenghui Zhang, Hong Fan, Mengqi Li
Published: Tuesday, December 26, 2023
Viewed: 2431
Effects of mitochondrial fusion and fission regulation on mouse hippocampal primary cultures: relevance to Alzheimer's disease
Alina Vadimovna Chaplygina, Daria Yurievna Zhdanova
Published: Friday, April 12, 2024
Viewed: 2377
Effects of mitochondrial fusion and fission regulation on mouse hippocampal primary cultures: relevance to Alzheimer's disease
Alina Vadimovna Chaplygina, Daria Yurievna Zhdanova
Published: Friday, April 12, 2024
Viewed: 2377
Ethylnitrosourea-induced gliomas: a song in the attic?
Yuji Ikeno
Published: Wednesday, June 28, 2023
Viewed: 2351
Nrf2 participates in progression of osteoarthritis through modulating redox balance
Yueqi Chen, Zihan Deng, Chuan Yang
Published: Thursday, September 28, 2023
Viewed: 2333
Nrf2 participates in progression of osteoarthritis through modulating redox balance
Yueqi Chen, Zihan Deng, Chuan Yang
Published: Thursday, September 28, 2023
Viewed: 2333
Serum elementomic analysis indicates a panel of elements related with age
Hui-Xian Sun, Kai-Yue Jia, Yan-Ru Li, Can Zhao, Xiang Lu, Wei Gao
Published: Friday, February 23, 2024
Viewed: 2274
Older-aged C57BL/6 mice fed a diet high in saturated fat and sucrose for ten months show decreased resilience to aging
Chloe N Johnson, Lida Zhu, Ruby Mangalindan, Jeremy Whitson, Maryia Sweetwyne, Ana P. Valencia, David J. Marcinek, Peter Rabinovitch, Warren Ladiges
Published: Thursday, September 28, 2023
Viewed: 2238
The case of a geriatric female experiencing frequent falls and epileptic seizures during long-term low-dose clozapine and extended-release bupropion treatment
Charisse Dzierba, Claudia Lee, Tammie Lee Demler
Published: Wednesday, June 28, 2023
Viewed: 2129
Biobased nanoemulsions for targeted drug delivery to treat dementia and aging
Joseph S. D'Arrigo
Published: Thursday, September 28, 2023
Viewed: 2074
Biobased nanoemulsions for targeted drug delivery to treat dementia and aging
Joseph S. D'Arrigo
Published: Thursday, September 28, 2023
Viewed: 2074
Negative health effects of low testosterone concentrations in older adults
Chieh Chen, Da-Ming Liao
Published: Thursday, February 29, 2024
Viewed: 2072
Research advances in stem cell transplantation combined with fibrin scaffold for treating spinal cord injury in an aging society
Yongxiong He, Tianqi Jiang, Zhijun Chen, Yitong Luo, Xinyue Tian, Hua Yang
Published: Thursday, March 7, 2024
Viewed: 2053
Exploring the complex interplay between anxiety, aging, and behavior in CB6F1 and C57BL/6 mice: implications for cognitive function
Gerald Yu Liao, Kunyuan Li, Addison Keely, Shuliang Yu, Christina Pettan-Brewer, Warren Ladiges
Published: Monday, March 25, 2024
Viewed: 2026
Physical resilience is a predictor of healthy aging
Warren Ladiges
Published: Thursday, September 28, 2023
Viewed: 2016
Voluntary wheel running is a non-invasive test to measure physical performance in aging mice
Christina Pettan-Brewer, Addison Keely, Warren Ladiges
Published: Tuesday, December 26, 2023
Viewed: 1999
Molecular docking and ADMET analysis of coenzyme Q10 as a potential therapeutic agent for Alzheimer's disease
Abdullah Al Noman, Pranab Dev Sharma, Tasmia Jahin Mim, Md Al Azad, Himanshu Sharma
Published: Thursday, December 26, 2024
Viewed: 1967
Molecular docking and ADMET analysis of coenzyme Q10 as a potential therapeutic agent for Alzheimer's disease
Abdullah Al Noman, Pranab Dev Sharma, Tasmia Jahin Mim, Md Al Azad, Himanshu Sharma
Published: Thursday, December 26, 2024
Viewed: 1967
Modeling resilience to sleep disruption to study resistance to Alzheimer’s disease
Warren Ladiges, Jordan Mazzola, Joo Young Park
Published: Tuesday, December 26, 2023
Viewed: 1965
Statins adherence and associated muscle symptoms in elderly coronary heart disease patients
Marat V Ezhov, Marina G. Bubnovaa, David M. Aronov
Published: Tuesday, December 26, 2023
Viewed: 1964
Exploring the interplay of leptin and aging: insights into the role of gut microbiota
Harish Rangareddy, Rajhi Hayfa, Venkateshappa Chikkanarayanappa, Ashakiran Srinivasaiah, Reshma Devarajachar
Published: Friday, April 12, 2024
Viewed: 1963
Exploring the interplay of leptin and aging: insights into the role of gut microbiota
Harish Rangareddy, Rajhi Hayfa, Venkateshappa Chikkanarayanappa, Ashakiran Srinivasaiah, Reshma Devarajachar
Published: Friday, April 12, 2024
Viewed: 1963
On the treatment of Parkinson’s disease—an interview with Prof. Nir Giladi
Siyan Chen
Published: Tuesday, December 26, 2023
Viewed: 1870
Technical development of senescence-associated β-galactosidase staining in frozen kidney tissue of Sprague Dawley rat
Yuji Ikeno, Ganga Tandukar, Lisa C. Flores, Colton Allen, Yidong Bai
Published: Tuesday, September 24, 2024
Viewed: 1861
2022 Reviewer Acknowledgment
Editorial Office of Aging Pathobiology and Therapeutics
Published: Thursday, December 29, 2022
Viewed: 1858
Resilience to aging drives personalized intervention strategies for Alzheimer’s disease
Warren Ladiges, Jackson Wezeman, Addison Keely
Published: Tuesday, December 26, 2023
Viewed: 1851
On epigenetic clocks and cancer risk—an interview with Prof. Andrew E. Teschendorf
Shikha Sharma
Published: Tuesday, December 26, 2023
Viewed: 1806
Effect of Pilates versus resistance training on physical fitness in older adults
Manisha Ashish Rathi, Khushboo Muthiyan, Reema Joshi, Preeti Gazbare
Published: Thursday, September 12, 2024
Viewed: 1791
On the growth of young geriatricians——an interview with Prof. Louis R. Caplan
Chan Rong
Published: Friday, December 1, 2023
Viewed: 1762
2023 Reviewer Acknowledgment
Editor Office of Aging Pathobiology and Therapeutics
Published: Tuesday, December 26, 2023
Viewed: 1717
Importance of coordination of regional stroke centers for acute ischemic stroke
Xin Xu, Yingjun Ouyang, Chan Rong
Published: Tuesday, December 26, 2023
Viewed: 1674
Impact of oral vitamin D3 supplementation on proximal femur fracture incidence in the elderly population
Hao Liu, Qingjun Qiu, Xuwen Luo, Bin Yuan
Published: Thursday, June 20, 2024
Viewed: 1627
Fasting helps nutrient sensing systems in clocking the metabolism
Neelu Jain Gupta
Published: Tuesday, June 25, 2024
Viewed: 1542
Fasting helps nutrient sensing systems in clocking the metabolism
Neelu Jain Gupta
Published: Tuesday, June 25, 2024
Viewed: 1542
The naturally occurring peptide GHK reverses age-related fibrosis by modulating myofibroblast function
Warren Ladiges, Qianpei He, Jordan Mazzola
Published: Thursday, December 26, 2024
Viewed: 1430
Focus on cytomegalovirus and cardiovascular diseases——an interview with Prof. Patricia Price
Ying Li, Jianwen Chen, Yujing Fang
Published: Tuesday, June 11, 2024
Viewed: 1400
Stricter definitions of myeloid senescence are needed
Brandt D. Pence
Published: Tuesday, June 18, 2024
Viewed: 1351
Behavioral and neuropathological features of Alzheimer’s disease are attenuated in 5xFAD mice treated with intranasal GHK peptide
Matthew Tucker, Gerald Yu Liao, Joo Young Park, Manuela Rosenfeld, Jackson Wezeman, Ruby Mangalindan, Dan Ratner, Martin Darvas, Warren Ladiges, Addison Keely
Published: Monday, August 26, 2024
Viewed: 1344
Periodontal disease, cardiovascular diseases and aging-the multidirectional link
Madhurya N Kedlaya, Reshma Suresh, Maya Rajan Peter, Lakshmi Puzhankara
Published: Tuesday, June 25, 2024
Viewed: 1299
Periodontal disease, cardiovascular diseases and aging-the multidirectional link
Madhurya N Kedlaya, Reshma Suresh, Maya Rajan Peter, Lakshmi Puzhankara
Published: Tuesday, June 25, 2024
Viewed: 1299
Improving human reproductive health and fertility——an interview with Prof. Marco G. Alves
Zijian Tian
Published: Thursday, May 30, 2024
Viewed: 1285
Machine learning paves the way forward for geropathology assessment
Gerald Yu Liao, Jenna Klug, Warren Ladiges
Published: Tuesday, June 4, 2024
Viewed: 1246
Withania somnifera: a promising neuroprotective ally against Alzheimer's disease
Rajaram Mohapatra, Pratikeswar Panda
Published: Thursday, December 26, 2024
Viewed: 1226
Withania somnifera: a promising neuroprotective ally against Alzheimer's disease
Rajaram Mohapatra, Pratikeswar Panda
Published: Thursday, December 26, 2024
Viewed: 1226
Diverse models in Alzheimer's research: exploring alternative approaches beyond traditional rodent frameworks
Govind Singh, Payal Chauhan, Karan Wadhwa
Published: Thursday, December 26, 2024
Viewed: 1041
Gut microbiome and neurodegenerative disorders: therapeutic Implications
Sugato Banerjee, Ritika Ruwatia, Suparna Roy Sarkar, Subhamoy Panda
Published: Thursday, November 21, 2024
Viewed: 992
Gut microbiome and neurodegenerative disorders: therapeutic Implications
Sugato Banerjee, Ritika Ruwatia, Suparna Roy Sarkar, Subhamoy Panda
Published: Thursday, November 21, 2024
Viewed: 992
The promise of adult neurogenesis for treating and preventing chronic neurodegenerative diseases
Warren Ladiges, Gerald Yu Liao
Published: Friday, September 13, 2024
Viewed: 991
Beyond hallmarks of aging – biological age and emergence of aging networks
S. Michal Jazwinski, Sangkyu Kim, Jessica Fuselier
Published: Monday, March 31, 2025
Viewed: 980
Beyond hallmarks of aging – biological age and emergence of aging networks
S. Michal Jazwinski, Sangkyu Kim, Jessica Fuselier
Published: Monday, March 31, 2025
Viewed: 980
Proteostasis in aging: mechanistic insights and therapeutic opportunities
Gaurav N. Kasar, Pooja B. Rasal, Chandrashekhar D. Patil, Sunil K. Mahajan, Aman B. Upaganlawar
Published: Thursday, March 6, 2025
Viewed: 948
Two-sample mendelian randomization study: vitamin D levels and chronic kidney disease in the elderly population
Ling Xiao, Kaiping Luo, Honghong Zou
Published: Sunday, September 29, 2024
Viewed: 872
The role of epigenetics in cognitive aging: mechanisms, interventions, and future directions
Abdullah Al Noman, Pranab Dev Sharma, Himanshu Sharma
Published: Friday, June 27, 2025
Viewed: 852
Metabolic dysfunction-associated steatotic liver disease of older people
Chieh Chen, Da-Ming Liao
Published: Friday, August 16, 2024
Viewed: 844
Metabolic dysfunction-associated steatotic liver disease of older people
Chieh Chen, Da-Ming Liao
Published: Friday, August 16, 2024
Viewed: 844
Towards clinical translation of biomarkers and therapies targeting autolysosomal acidification dysfunction in neuroinflammation and neurodegeneration—an interview with Prof. David Rubinsztein
Chih Hung Lo
Published: Sunday, September 29, 2024
Viewed: 831
A natural way for a healthier lifestyle—an interview with Prof. Stephen C. Bondy
Alessandro Bitto
Published: Friday, August 16, 2024
Viewed: 829
Cartilage organoid model of osteoarthritis to study aging-related diseases
Guangxuan Yan, Yongxiong He, Zhiqiang Shi, Yuan Li, Kai Tao, Jun Fan, Qiankun Zhu, Heng Wang, Aitao Wang, Yongchao Li
Published: Friday, June 27, 2025
Viewed: 815
Targeting metabolic function to improve aging and healthspan: 2024 Masoro-barshop conference on aging
Adam Salmon
Published: Thursday, December 26, 2024
Viewed: 814
Myrmecodia platytyrea tuber aqueous extract exacerbates neuroinflammation
Mizaton Hazizul Hasan, Aisyah Hasyila Jahidin, Hanish Singh Jayasingh Chellammal, Ayuni Nordin, Suraya Suratman, Mohd Faiz Mustaffa
Published: Monday, February 10, 2025
Viewed: 796
Myrmecodia platytyrea tuber aqueous extract exacerbates neuroinflammation
Mizaton Hazizul Hasan, Aisyah Hasyila Jahidin, Hanish Singh Jayasingh Chellammal, Ayuni Nordin, Suraya Suratman, Mohd Faiz Mustaffa
Published: Monday, February 10, 2025
Viewed: 796
From plants to potential therapeutics: exploring neuroprotective properties against Alzheimer’s disease through molecular docking and MD simulations
Ashwani Kumar, Shubham Kumar, Aanchal Gupta, Chirag N. Patel, Vikas Kumar
Published: Friday, June 27, 2025
Viewed: 795
Exploring the neuroprotective potential of an iota-carrageenan in in vitro Parkinson's disease model: evaluation of pharmacological safety, antioxidant properties, and mitochondrial function
Ricardo Basto Souza, Joana Silva, Celso Alves, Agnieszka Zofia Neugebauer, Vitória Virgínia Magalhães Soares, Raimundo Rafael de Almeida, Nágila Maria Pontes Silva Ricardo, Norma Maria Barros Benevides, Rui Pedrosa
Published: Monday, February 10, 2025
Viewed: 789
Exploring the neuroprotective potential of an iota-carrageenan in in vitro Parkinson's disease model: evaluation of pharmacological safety, antioxidant properties, and mitochondrial function
Ricardo Basto Souza, Joana Silva, Celso Alves, Agnieszka Zofia Neugebauer, Vitória Virgínia Magalhães Soares, Raimundo Rafael de Almeida, Nágila Maria Pontes Silva Ricardo, Norma Maria Barros Benevides, Rui Pedrosa
Published: Monday, February 10, 2025
Viewed: 789
Inflammaging and microbiota: the intersection of aging, inflammation, and gut health
Harish Rangareddy, Jessica Fryer, Achal Shetty, Hayfa Rajhi
Published: Friday, June 27, 2025
Viewed: 777
A change is needed in the landscape of preclinical models to test drugs that target aging
Warren Ladiges
Published: Thursday, December 26, 2024
Viewed: 761
Endotoxin-induced acute lung injury in old C57BL/6J mice is a translationally relevant geroscience model
Warren Ladiges, Qianpei He, Ruby S. Mangalindan, Jenna Klug
Published: Tuesday, March 18, 2025
Viewed: 742
Autophagy in neurodegeneration: recent advances, autophagosome formation, and therapeutic innovations—an interview with Prof. David Rubinsztein
Aracely Garcia-Garcia
Published: Thursday, December 26, 2024
Viewed: 731
Revisiting mitochondrial dysfunction in aging biology research
Brandt D. Pence, Yufeng Zhang
Published: Monday, March 24, 2025
Viewed: 683
2024 Reviewer Acknowledgment
Editor Office of Aging Pathobiology and Therapeutics
Published: Thursday, December 26, 2024
Viewed: 676
Effect of dual task training versus analogy training on gait speed and balance in older adults—randomized controlled trial
Yashi Shah, Reema Joshi, Chetana Tetgure
Published: Saturday, December 14, 2024
Viewed: 628
The neuropathology of aging and Alzheimer’s disease in domestic cats
Warren Ladiges, Ankita Sharma
Published: Friday, June 27, 2025
Viewed: 435
Effects of structured group reminiscence in sports and non-sports environments on cognitive empowerment and optimism in older adults: a quasi-experimental study
Bahador Azizi, Amin Azimkhani, Mohammad Khazaei, Saleh Moazam, Nazli Ilchizadeh, Katarzyna Dzioban
Published: Friday, June 27, 2025
Viewed: 390
The estimation of the clinical status of the residents in a geriatric health service facility in Japan
Toyoki Maeda
Published: Friday, June 27, 2025
Viewed: 373
Biomarkers for prognostic stratification in chronic heart failure in older patients
Anton R. Kiselev, Kseniya D. Dorogoykina
Published: Friday, June 27, 2025
Viewed: 360
Experimental confirmation of osteoarthritis repair in vivo using epigenetic reprogramming with small molecules
Javdat N. Muratkhodjaev, Saodat A. Muratkhodjaeva, Tamara U. Aripova
Published: Monday, September 8, 2025
Viewed: 338
Integrative bioinformatics and molecular docking unveil multi-target therapeutic mechanisms of Coptidis Rhizoma (CR) against Lewy body dementia (LBD): an in-silico approach
Pranab Dev Sharma, Abdullah Al Noman
Published: Friday, June 6, 2025
Viewed: 284
Pharmacologic activation of delta133p53α reduces cellular senescence in progeria patients-derived cells
Sebastien M. Joruiz, Patricia K. Dranchak, Natalia Von Muhlinen, Curtis C. Harris, Izumi Horikawa, James Inglese, Delphine Lissa
Published: Tuesday, September 16, 2025
Viewed: 208
Resilience in the depths: anemones as models for aging and regeneration research
Pooja B. Rasal, Gaurav N. Kasar, Durgesh S. Pagar, Aman B. Upaganlawar, Sunil K. Mahajan
Published: Friday, July 18, 2025
Viewed: 198
Epigenetic mechanisms of the influence of aging on the development of breast cancer with the participation of retroelements
Rustam Nailevich Mustafin
Published: Friday, August 15, 2025
Viewed: 159
Epigenetic mechanisms of the influence of aging on the development of breast cancer with the participation of retroelements
Rustam Nailevich Mustafin
Published: Friday, August 15, 2025
Viewed: 159
Expanding the clinical implications of biomarkers and physiological indicators in geriatric institutionalization
Jitendra Kumar Sinha, Shampa Ghosh, Krishna Kumar Singh
Published: Thursday, September 11, 2025
Viewed: 121
Sarcopenia and intrinsic capacity in aging: implications for geriatric physiotherapy assessment and care
Weslley Barbosa Sales, Melissa Silva Rocha Pereira
Published: Friday, August 29, 2025
Viewed: 117
Effect of continuous illumination on the ultrastructure of rat hepatocytes during ontogenesis
David A. Areshidzea, Maria A Kozlova
Published: Friday, September 12, 2025
Viewed: 116
Dysregulation of Nrf2/ARE pathway and mitochondrial DNA damage in aging and Alzheimer’s-associated cognitive decline
Polina I. Babenkova, Veronika V. Nesterova, Arina D. Tsvetkova, Anna A. Eremina, Artem P. Gureev, Vera A. Kryukova, Irina S. Sadovnikova
Published: Monday, September 29, 2025
Viewed: 77
Cigarette exposure and aging pathways: interplay between IGF-1 suppression and TGF-β increase
Titiek Hidayati, Akrom Akrom, Suny Sun
Published: Sunday, September 28, 2025
Viewed: 66
Predicting resilience to aging with physical stressors
Warren Ladiges
Published: Friday, September 26, 2025
Viewed: 55