Most Viewed Articles
Mini Review Drug nanotargeting for treatment of neurodegeneration and aging Joseph S. D'Arrigo Published: Tuesday, June 29, 2021 Viewed: 21840
Therapeutic Brief The potential of GHK as an anti-aging peptide Warren Ladiges, Yan Dou, Amanda Lee, Lida Zhu, John Morton Published: Friday, March 27, 2020 Viewed: 7036
Conference Abstract Resilience in aging and age-related disease. Abstracts from the 2019 Barshop Conference on Aging Warren Ladiges, Yuji Ikeno, Liang Wang Published: Friday, March 27, 2020 Viewed: 5640
Research Article Sleep-deprived cognitive impairment in aging mice is alleviated by rapamycin Warren Ladiges, Kishore Mukherjee, Amanda Lee, Lida Zhu, Martin Darvas Published: Monday, December 30, 2019 Viewed: 5620
Review The rationale for testing drug combinations in aging intervention studies Kavita C Sharma, Juan Wang, Zhou Jiang, Jenna Klug, Martin Darvas, Denise M Imai, Timothy Snider, Laura Niedernhofer, Warren C Ladiges Published: Monday, December 30, 2019 Viewed: 5202
Review Development of a Geropathology Grading Platform for nonhuman primates Warren Ladiges, Katie J Olstad, Denise M Imai, Rebekah I Keesler, Rachel Reader, John H Morrison, Jeffery A Roberts, John P Capitanio, Elizabeth S Didier, Marcelo J Kuroda, Heather Simmons, Shabnam Salimi, Julie A Mattison, Yuji Ikeno Published: Friday, March 27, 2020 Viewed: 5179
Case Report Novel LMNA mutations in Greek and Myanmar Patients with Progeroid Features and Cardiac Manifestations Junko Oshima, Renuka Kandhaya-Pillai, Fuki M Hisama, Stephanie A Bucks, Soe Yarzar, Haroula Korovou, George M Martin Published: Monday, June 29, 2020 Viewed: 5100
Research Article Highly expressed ribosomal protein L34 predicts poor prognosis in acute myeloid leukemia and could be a potential therapy target Liang Wang, Jing Yang, Henan Wang, Weida Wang, Xiaojie Liang Published: Friday, March 27, 2020 Viewed: 4927
Research Article Thioredoxin overexpression in mitochondria showed minimum effects on aging and age-related diseases in male C57BL/6 mice Madeline G. Roman, Lisa C. Flores, Geneva M. Cunningham, Christie Cheng, Sara Dube, Colton Allen, Holly Van Remmen, Yidong Bai, Thomas L. Saunders, Yuji Ikeno Published: Friday, March 27, 2020 Viewed: 4820
Research Article Interfering with miR-24 alleviates rotenone-induced dopaminergic neuron injury via enhancing autophagy by upregulating DJ-1 Fengrui Li, Biao Ge, Hairong Wu, Dan Shao, Shulin Li Published: Monday, December 30, 2019 Viewed: 4429
Case Report Drug-Induced Hemolytic Crisis During Ibrutinib plus Venetoclax for the Treatment of Mantle-Cell Lymphoma: A Rare Hematologic Adverse Reaction Xin Wen, Liang Wang, Yingzhi He, Shan Wang Published: Monday, December 30, 2019 Viewed: 4295
Technology Feature QuPath. A new digital imaging tool for geropathology Warren Ladiges, Amanda Lee, Zhou Jiang, Lida Zhu Published: Monday, June 29, 2020 Viewed: 4259
Research Article MicroRNA-152 suppresses cell proliferation and tumor growth of bladder cancer by targeting KLF5 and MKK7 Liangliang Wang, Yu Hui, Yuhua Huang, Xiang Ding Published: Monday, December 30, 2019 Viewed: 4230
Editorial Time for an Alzheimer’s disease cocktail Warren Carl Ladiges Published: Friday, March 27, 2020 Viewed: 4214
Research Article Down-regulation of miR-181a promotes microglial M1 polarization through increasing expression of NDRG2 Bo Zhou, Yali Niu, Chunxiao Wan, Rui wu, Heying Sun, Danqing Lu Published: Friday, March 27, 2020 Viewed: 4115
Research Article LINC00271 inhibits epithelial-mesenchymal transition of papillary thyroid cancer cells by downregulating trefoil factor 3 expression Jianda Dong, Pihong Li, Xiaoyu Pan, Zhouci Zheng, Yihan Sun, Yifan Han Published: Monday, June 29, 2020 Viewed: 4096
Research Article Mitochondrial-targeted methionine sulfoxide reductase overexpression increases the production of oxidative stress in mitochondria from skeletal muscle Adam B. Salmon, Arunabh Bhattacharya, Daniel Pulliam, Yuhong Liu Published: Friday, March 27, 2020 Viewed: 4012
Review Aging pet cats develop neuropathology similar to human Alzheimer’s disease Warren Ladiges, Jenna Klug, Jessica M. Snyder, Martin Darvas, Denise M. Imai, Molly Church, Caitlin Latimer, C . Dirk Keene Published: Tuesday, September 29, 2020 Viewed: 3615
Review Guidelines for the Prevention of Coronavirus Pneumonia in Elderly People Wei Ma, Jun Zhao, Gang Xu, Congrui Feng, Yuluo Chen, Feng Liu Published: Monday, June 29, 2020 Viewed: 3415
Model Profile A mouse model of sleep deprived neuropathology to study resilience to Alzheimer’s disease Warren Ladiges, Yan Dou, Jinzi Wu, Lida Zhu, Martin Darvas Published: Monday, June 29, 2020 Viewed: 3409
Research Article IL-17 regulates the expression of major histocompatibility complex II and VEGF in DLBCL mice on tumor growth Xin Xu, Ting Wei, Weijie Zhong, Zhigang Zhu, Feng Liu, Qingshan Li Published: Monday, June 29, 2020 Viewed: 3396
Editorial Oxidative stress in aging: stayin’ alive? Lisa C. Flores, Yuji Ikeno Published: Monday, June 29, 2020 Viewed: 3389
Review Thioredoxin and aging: What have we learned from the survival studies? Lisa C. Flores, Madeline G. Roman, Geneva M. Cunningham, Christie Cheng, Colton Allen, Gene Borden Hubbard, Yidong Bai, Thomas L. Saunders, Yuji Ikeno Published: Tuesday, September 29, 2020 Viewed: 3383
Technology Feature An immune stress test for resilience to aging: Pneumococcal vaccine response Warren Ladiges, Ryan Oveson, Zhou Jiang, Michali Izhak, Kavita Sharma Published: Tuesday, September 29, 2020 Viewed: 3330
Research Article Finding prodromal frailty in a community-dwelling healthy older cohort by survey of BDNF or hand grip strength classified by BMI Mitsugu Hachisu, Masahiro Hashizume, Hisashi Kawai, Motonaga Kojima, Yoshinori Fujiwara, Shuichi Obuchi, Mari Kogo, Masayuki Ohbayashi, Noriko Koyama, Miki Takenaka, Kazushige Ihara Published: Tuesday, September 29, 2020 Viewed: 3220
Review Gastrointestinal Disasters of Cetuximab in the Treatment of Metastatic Colorectal Cancer: Mechanism and its Effect on Prognosis Junfeng Sun, Yue Wu, Haowei Jia, Xinqi Bao, Tianyu Zhu, Ruixin Li, Hongchao Zhao Published: Monday, June 29, 2020 Viewed: 3199
Model Profile A model for studying cutaneous wound healing and resilience to aging: Ear punch biopsy in old mice Warren Ladiges, Zhou Jiang, Jessie Chen, Juan Wang, Ruby Mangalindan, Lida Zhu Published: Tuesday, September 29, 2020 Viewed: 3185
Therapeutic Brief Short-term oral rapamycin prevents age-related learning impairment in mice Warren Ladiges, Haoyi Lei, Juan Wang, Zhou Jiang Published: Tuesday, September 29, 2020 Viewed: 3140
Commentary A geropathology approach for identifying therapeutic targets to prevent pathological complications of COVID-19 Warren Ladiges, Yuji Ikeno, Liang Wang, Feng Liu Published: Monday, June 29, 2020 Viewed: 3108
Review The cellular senescence unification model and telomerase therapy: To treat all age-related diseases Steve Liebich Published: Tuesday, September 29, 2020 Viewed: 3073
Research Article Anti-tumor effect of pcDNA3.1(-)/rMETase-shUCA1 hyaluronic acid-modified G5 polyamidoamine nanoparticles on gastric cancer Chunying Xie, Zhenxing Huang, Zhaohui Huang, Yanyan Guo, Xue Zhang Published: Monday, June 29, 2020 Viewed: 3066
Research Article Resilience to acute sleep deprivation is associated with attenuation of hippocampal mediated learning impairment Warren Ladiges, Amanda Lee, Haoyi Lei, Lida Zhu, Zhou Jiang Published: Thursday, December 31, 2020 Viewed: 3063
Therapeutic Brief The potential of XPO1 inhibitors as a game changer in relapsed/refractory hematologic malignancies Henan Wang, Liang Wang, Jing Yang Published: Monday, June 29, 2020 Viewed: 3039
Therapeutic Brief Physical performance is enhanced in old mice fed a short term diet medicated with rapamycin, acarbose, and phenylbutyrate Warren Ladiges, Megan Ellis, Zhou Jiang Published: Monday, March 29, 2021 Viewed: 3036
Geropathology Notes Eosinophilic crystalline pneumonia, an age-related lesion in mice Jenna J Klug, Jessica M Snyder Published: Thursday, December 31, 2020 Viewed: 2977
Review Myocardial Cell Aging in the Elderly Feng Liu, Wenxi Li Published: Tuesday, September 29, 2020 Viewed: 2917
Research Article Sex-dependent lifespan extension of ApcMin/+ FAP mice by chronic mTOR inhibition Manish Parihar, Sherry G Dodds, Marty Javors, Randy Strong, Paul Hasty, Zelton Dave Sharp Published: Thursday, December 31, 2020 Viewed: 2900
Model Profile Neutrophil response to cyclophosphamide predicts resilience to age-related learning impairment Lida Zhu, Warren Ladiges, Katie Nickel, Marianne Bjorner Published: Thursday, December 31, 2020 Viewed: 2816
Case Report Irreversible effects of anticholinergic withdrawal in the elderly: a case report Charisse Chehovich, Claudia Lee, Tammie Lee Demler Published: Tuesday, June 29, 2021 Viewed: 2786
Editorial Immunotherapy: the blockbuster in cancer treatment Liang Wang Published: Tuesday, September 29, 2020 Viewed: 2677
Research Article miR-181c inhibits prostatic epithelial cell proliferation caused by chronic non-bacterial prostatitis through down-regulating COX-2 Xiang Ding, Xu Xu, Yuhua Huang, Jianquan Hou, Jinxing Lv Published: Thursday, December 31, 2020 Viewed: 2673
Therapeutic Brief Gam-COVID-Vac (Sputnik V): a heterologous adenoviral vector-based COVID-19 vaccine Shyh Poh Teo, Sanny Zi Lung Choo Published: Tuesday, June 29, 2021 Viewed: 2673
Geropathology Notes Hepatic steatosis, a lesion reported in captive aged common marmosets Sebastian Eduardo Carrasco, Olga Lucia Franco-Mahecha Published: Monday, March 29, 2021 Viewed: 2621
Case Report Spontaneous chordoma: a case report on a female UM-HET3 mouse from the SLAM study Eleonora Duregon, Rafael de Cabo, Camila Vieira Ligo Teixeira, Dushani L. Palliyaguru, Annamaria L. Rudderow, Victoria Hoffmann, Michel Bernier, Nathan L. Price, Simonetta Camandola Published: Thursday, December 31, 2020 Viewed: 2610
Review Application and research progress of BCL2 inhibitors in elderly patients with hematologic malignancies Liang Wang, Yufan Wang Published: Thursday, December 31, 2020 Viewed: 2583
Therapeutic Brief Denosumab for the treatment of osteoporosis Shyh Poh Teo Published: Tuesday, September 29, 2020 Viewed: 2581
Case Report Coronary artery stenosis regression by long-term standard dose statin therapy in middle-aged and elderly patients: Report and analysis of 31 cases Feng Liu, Zhilei Ren, Chongzhe Yang, Kaihua Huang Published: Tuesday, September 29, 2020 Viewed: 2577
Editorial Progress in drug treatment of elderly chronic heart failure Feng Liu, Siting Zhang Published: Thursday, December 31, 2020 Viewed: 2577
Reviewer Acknowledgement 2020 Reviewer Acknowledgment Editorial Office of Aging Pathobiology and Therapeutics Published: Thursday, December 31, 2020 Viewed: 2555
Review Recent advances in the genetic association between osteoporotic fracture and sarcopenia Qiaocong Chen, Huiling Lou, Cheng Peng Published: Monday, March 29, 2021 Viewed: 2536
Research Article Thioredoxin down-regulation in the cytosol in thioredoxin 2 transgenic mice did not have beneficial effects to extend lifespan in male C57BL/6 mice Lisa C. Flores, Madeline G. Roman, Geneva M. Cunningham, Christie Cheng, Colton Allen, Yidong Bai, Gene B. Hubbard, Yuji Ikeno Published: Thursday, December 31, 2020 Viewed: 2525
Editorial Harnessing the heterogeneity of aging Warren Ladiges Published: Monday, March 29, 2021 Viewed: 2522
Case Report Castleman disease with rapidly progressive pemphigus: case report Liang Wang, Ruiying Fu, Yingzhi He Published: Thursday, December 31, 2020 Viewed: 2491
Letter to Editor Optimal induction treatment regimens for extranodal NK/T-cell lymphoma: lessons learned, challenges, and proposals Liang Wang, Jing Yang, Ruiying Fu, Xindi Liu, Liqiang Wei Published: Thursday, December 31, 2020 Viewed: 2484
Letter to Editor Arthritis as an adverse event of special interest post COVID-19 vaccine implementation Shyh Poh Teo Published: Monday, March 29, 2021 Viewed: 2459
Review Safety and efficacy of the Novavax vaccine—a narrative review Shyh Poh Teo, Sanny Zi Lung Choo Published: Friday, December 31, 2021 Viewed: 2206
Research Article KDClassifier: A urinary proteomic spectra analysis tool based on machine learning for the classification of kidney diseases Wanjun Zhao, Yong Zhang, Xinming Li, Yonghong Mao, Changwei Wu, Lijun Zhao, Fang Liu, Jingqiang Zhu, Jingqiu Cheng, Hao Yang, Guisen Li Published: Thursday, September 30, 2021 Viewed: 2109
Research Article Association of anemia with rehabilitation outcome for subacute geriatric rehabilitation patients in a secondary hospital in malaysia Mann Leon Chin, Christopher WS Chan, Huey Ee Chong, Wee Kooi Cheah Published: Friday, December 31, 2021 Viewed: 2064
Case Report Cardiac arrest in an older male patient treated with flecainide for atrial fibrillation Tiziana Ciarambino, Rosario Bottone, Gennaro Sansone, Mauro Giordano Published: Tuesday, June 29, 2021 Viewed: 2023
Research Article Di-2-pyridylketone 4, 4-dimethyl-3-thiosemicarbazone effectively induces human colorectal carcinoma cell apoptosis via mTOR pathway Qianqian Fu, Shengli Wang, Chuyun Zhu, Zhenlong Zhou, Xiaojuan Yu, Yong Zhang Published: Thursday, September 30, 2021 Viewed: 1998
Research Article PathoClock and PhysioClock in mice recapitulate human multimorbidity and heterogeneous aging Warren Ladiges, Shabnam Salimi, Christina Pettan-Brewer Published: Friday, December 31, 2021 Viewed: 1982
Commentary Precision aging. Human lifespan has intrinsic limits but measurable outcomes Warren Ladiges Published: Tuesday, June 29, 2021 Viewed: 1963
Therapeutic Brief The antidiabetic drug acarbose suppresses age-related lesions in C57BL/6 mice in an organ dependent manner Zhou Jiang, Sneh Gupta, Warren Ladiges Published: Tuesday, June 29, 2021 Viewed: 1950
Editorial Chimeric antigen receptor T cell therapy in cancer: Advances and challenges Yuanzheng Liang, Liang Wang Published: Thursday, September 30, 2021 Viewed: 1925
Editorial Thioredoxin – a magic bullet or a double-edged sword for mammalian aging? Yuji Ikeno Published: Tuesday, June 29, 2021 Viewed: 1898
Review Progress on the study of fibroblast growth factors as novel therapeutics in post-stroke cognitive impairment Hong Fan, Mengqi Li Published: Thursday, September 30, 2021 Viewed: 1886
Case Report A fornix infarction causing post-operative anterograde amnesia Shyh Poh Teo Published: Tuesday, June 29, 2021 Viewed: 1882
Case Report Older female relatives of Covid-19 patients have an un-satisfactory perception of emergency room performance by clinical staff Tiziana Ciarambino, Luigia Palmiero, Rosario Bottone, Federico Schettini, Luigi Elio Adinolfi, Mauro Giordano Published: Tuesday, June 29, 2021 Viewed: 1848
Review Advances in targeting programmed cell death 1/programmed cell death-ligand 1 therapy for hematological malignancies Liang Wang, Yuanzheng Liang, Wanying Zhao Published: Friday, December 31, 2021 Viewed: 1816
Research Article Clinical diagnosis and treatment of primary small intestinal lymphoma Guitian Huang Published: Thursday, September 30, 2021 Viewed: 1714
Commentary Mouse modeling for anxiety disorders in older adults Martin Darvas, Warren Ladiges, Nadia Postupna Published: Thursday, September 30, 2021 Viewed: 1701
Commentary The unrecognized potential of pet cats for studying aging and age-related diseases Warren Ladiges Published: Friday, December 31, 2021 Viewed: 1677
Commentary Resilience to aging is a heterogeneous characteristic defined by physical stressors Haoyi Lei, Derek M. Huffman, Adam B. Salmon, Nathan K. LeBrasseur, Christy Carter, Arlan Richardson, Steve Austad, Warren Ladiges Published: Wednesday, March 30, 2022 Viewed: 1660
Commentary Geropathology. An inside view of biological aging Warren Ladiges Published: Wednesday, March 30, 2022 Viewed: 1464
Letter to Editor Preventive effect of rehabilitation training therapy on muscle quality in patients with stroke: A retrospective study Xiang Lu, Dandan Feng, Wei Gao, Can Zhao, Dan Chen, Xiaojing He Published: Friday, December 31, 2021 Viewed: 1455
Editorial Microbiome in aging of Gut and Brain (MiaGB): paving the ways to understand gut-brain axis in aging Michal M. Masternak, Hariom Yadav Published: Wednesday, March 30, 2022 Viewed: 1448
Review Mechanisms of autophagy regulation by adiponectin Xin Xu, Chan Rong Published: Friday, December 31, 2021 Viewed: 1382
Conference Abstract The aging immune system. Abstracts presented at the Masoro-Barshop conference on aging, October 13-15, 2021 Warren Ladiges Published: Friday, December 31, 2021 Viewed: 1310
Research Article Leucine metabolite β-hydroxy-β-methyl butyrate (HMB) supplementation on muscle mass during resistance training in older subjects: meta-analysis Guangqin Zou, Quan Wang, Hua Wan, Xiang Lu, Wei Gao Published: Wednesday, March 30, 2022 Viewed: 1308
Reviewer Acknowledgement 2021 Reviewer Acknowledgment Editorial Office of Aging Pathobiology and Therapeutics Published: Friday, December 31, 2021 Viewed: 1232
Case Report Nasal type extranodal natural killer/T-cell lymphoma-associated hemophagocytic lymphohistiocytosis: a Case report and literature review Xuelin Liu, Liqiang Wei, Jing Yang, Jin Ye, Liang Wang Published: Wednesday, March 30, 2022 Viewed: 1003
Commentary Pharmaceutical interventions to slow human aging. Are we ready for cocktails? Warren Ladiges, Manuela Rosenfeld Published: Thursday, June 30, 2022 Viewed: 899
Editorial Get back–calorie restriction: Dr. Masoro’s legacy Yuji Ikeno, Lisa C. Flores Published: Thursday, June 30, 2022 Viewed: 658
Review Vitiligo as a potential degenerative disease: from oxidative stress to cellular senescence Yaojun Wang, Jiaoni Chi, Tao Wang, Yue Zhang, Zhimin Li, Jie Chen, Haixia Liu, Qiang Li Published: Thursday, June 30, 2022 Viewed: 616
Mini Review Sotrovimab for treatment of COVID-19 infections Shyh Poh Teo Published: Thursday, June 30, 2022 Viewed: 490
Review Research progress in the PD-1/PD-L1 pathway and IL-17A in lymphomas Li Yang, Xin Xu Published: Thursday, June 30, 2022 Viewed: 461
Research Article Long-term treatment with Elamipretide enhances healthy aging phenotypes in mice Kaitlin Nickel, Lida Zhu, Ruby Mangalindan, Jessica M. Snyder, Jeremy Whitson, Maryia Sweetwyne, Ana P. Valencia, Jenna Klug, Zhou Jiang, David J. Marcinek, Peter Rabinovitch, Warren Ladiges, Matthew Tucker Published: Friday, September 30, 2022 Viewed: 461
Research Article A reappraisal of the measured concentration of voriconazole based on plasma albumin concentration during its therapeutic drug monitoring Fangmin Xu, Yexuan Wang, Xiaoshan Zhang, Junhui Yu, Liwen Zhang, Xuben Yu, Haina Zhang Published: Thursday, June 30, 2022 Viewed: 417
Model Profile A mouse model of naturally occurring age-related cognitive impairment Sara Daneshjoo, Jualiana Moreno, Manuela Rosenfeld, Joo Young Park, Martin Darvas, Warren Ladiges Published: Friday, September 30, 2022 Viewed: 304
Review The critical role of macrophages in ovarian cancer treatment Yiran Wang, Mingyi Wang Published: Friday, September 30, 2022 Viewed: 289
Review Sarcopenia and falls in older adults Chieh Chen, Daming Liao Published: Friday, September 30, 2022 Viewed: 277
Editorial Targeting metabolism through exercise and nutrition to rejuvenate an aging immune system Brandt D. Pence Published: Friday, September 30, 2022 Viewed: 259
Interview On the growth of young neurologists—an interview with Prof. Louis R. Caplan Qi Qin Published: Friday, September 30, 2022 Viewed: 232
Commentary Sex Matters in Aging. The Canagliflozin Story Warren Ladiges, Jackson Wezeman Published: Friday, September 30, 2022 Viewed: 216
Interview On the frontier of immunogerontology—an interview with Prof. Graham Pawelec Xiaodong Li Published: Friday, September 30, 2022 Viewed: 161
Commentary The Eph receptor A4-mediated demyelination in depression Quanguang Zhang, Luodan Yang Published: Wednesday, November 2, 2022 Viewed: 80
Interview On the frontier of chronic obstructive pulmonary disease—an interview with Prof. Peter J Barnes Wei Ma Published: Thursday, October 27, 2022 Viewed: 79
Review Influence of metformin on age-related macular degeneration Albert J Augustin, Jenny Atorf Published: Wednesday, November 30, 2022 Viewed: 8


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