Most Viewed Articles
The potential of GHK as an anti-aging peptide
Warren Ladiges, Yan Dou, Amanda Lee, Lida Zhu, John Morton
Published: Friday, March 27, 2020
Viewed: 5024
Resilience in aging and age-related disease. Abstracts from the 2019 Barshop Conference on Aging
Warren Ladiges, Yuji Ikeno, Liang Wang
Published: Friday, March 27, 2020
Viewed: 4633
Sleep-deprived cognitive impairment in aging mice is alleviated by rapamycin
Warren Ladiges, Kishore Mukherjee, Amanda Lee, Lida Zhu, Martin Darvas
Published: Monday, December 30, 2019
Viewed: 4620
Development of a Geropathology Grading Platform for nonhuman primates
Warren Ladiges, Katie Olstad, Denise Imai, Rebekah Keesler, Rachel Reader, John Morrison, Jeffery Roberts, John Capitanio, Elizabeth Didier, Marcelo Kuroda, Heather Simmons, Shabnam Salimi, Julie Mattison, Yuji Ikeno
Published: Friday, March 27, 2020
Viewed: 4377
The rationale for testing drug combinations in aging intervention studies
Kavita Sharma, Juan Wang, Zhou Jiang, Jenna Klug, Martin Darvas, Denise Imai, Timothy Snider, Laura Niedernhofer, Warren Ladiges
Published: Monday, December 30, 2019
Viewed: 4108
Highly expressed ribosomal protein L34 predicts poor prognosis in acute myeloid leukemia and could be a potential therapy target
Liang Wang, Jing Yang, Henan Wang, Weida Wang, Xiaojie Liang
Published: Friday, March 27, 2020
Viewed: 4001
Thioredoxin overexpression in mitochondria showed minimum effects on aging and age-related diseases in male C57BL/6 mice
Madeline Roman, Lisa Flores, Geneva Cunningham, Christie Cheng, Sara Dube, Colton Allen, Holly Van Remmen, Yidong Bai, Thomas Saunders, Yuji Ikeno
Published: Friday, March 27, 2020
Viewed: 3972
Novel LMNA mutations in Greek and Myanmar Patients with Progeroid Features and Cardiac Manifestations
Junko Oshima, Renuka Kandhaya-Pillai, Fuki Hisama, Stephanie Bucks, Soe Yarzar, Haroula Korovou, George Martin
Published: Monday, June 29, 2020
Viewed: 3802
Interfering with miR-24 alleviates rotenone-induced dopaminergic neuron injury via enhancing autophagy by upregulating DJ-1
Fengrui Li, Biao Ge, Hairong Wu, Dan Shao, Shulin Li
Published: Monday, December 30, 2019
Viewed: 3545
Drug-Induced Hemolytic Crisis During Ibrutinib plus Venetoclax for the Treatment of Mantle-Cell Lymphoma: A Rare Hematologic Adverse Reaction
Xin Wen, Liang Wang, Yingzhi He, Shan Wang
Published: Monday, December 30, 2019
Viewed: 3523
MicroRNA-152 suppresses cell proliferation and tumor growth of bladder cancer by targeting KLF5 and MKK7
Liangliang Wang, Yu Hui, Yuhua Huang, Xiang Ding
Published: Monday, December 30, 2019
Viewed: 3403
Down-regulation of miR-181a promotes microglial M1 polarization through increasing expression of NDRG2
Bo Zhou, Yali Niu, Chunxiao Wan, Rui wu, Heying Sun, Danqing Lu
Published: Friday, March 27, 2020
Viewed: 3288
QuPath. A new digital imaging tool for geropathology
Warren Ladiges, Amanda Lee, Zhou Jiang, Lida Zhu
Published: Monday, June 29, 2020
Viewed: 3280
Time for an Alzheimer’s disease cocktail
Warren Ladiges
Published: Friday, March 27, 2020
Viewed: 3224
Mitochondrial-targeted methionine sulfoxide reductase overexpression increases the production of oxidative stress in mitochondria from skeletal muscle
Adam Salmon, Arunabh Bhattacharya, Daniel Pulliam, Yuhong Liu
Published: Friday, March 27, 2020
Viewed: 3160
Pioglitazone up-regulates MALAT1 and promotes the proliferation of endothelial progenitor cells through increasing c-Myc expression in type 2 diabetes mellitus
Xiaoxu Yang, Chen Hu, Yan Sun
Published: Friday, March 27, 2020
Viewed: 3032
LINC00271 inhibits epithelial-mesenchymal transition of papillary thyroid cancer cells by downregulating trefoil factor 3 expression
Jianda Dong, Pihong Li, Xiaoyu Pan, Zhouci Zheng, Yihan Sun, Yifan Han
Published: Monday, June 29, 2020
Viewed: 3008
Aging pet cats develop neuropathology similar to human Alzheimer’s disease
Warren Ladiges, Jenna Klug, Jessica M. Snyder, Martin Darvas, Denise M. Imai, Molly Church, Caitlin Latimer, C . Dirk Keene
Published: Tuesday, September 29, 2020
Viewed: 2833
Guidelines for the Prevention of Coronavirus Pneumonia in Elderly People
Wei Ma, Jun Zhao, Gang Xu, Congrui Feng, Yuluo Chen, Feng Liu
Published: Monday, June 29, 2020
Viewed: 2807
A mouse model of sleep deprived neuropathology to study resilience to Alzheimer’s disease
Warren Ladiges, Yan Dou, Jinzi Wu, Lida Zhu, Martin Darvas
Published: Monday, June 29, 2020
Viewed: 2776
Oxidative stress in aging: stayin’ alive?
Lisa Flores, Yuji Ikeno
Published: Monday, June 29, 2020
Viewed: 2774
IL-17 regulates the expression of major histocompatibility complex II and VEGF in DLBCL mice on tumor growth
Xin Xu, Ting Wei, Weijie Zhong, Zhigang Zhu, Feng Liu, Qingshan Li
Published: Monday, June 29, 2020
Viewed: 2640
Finding prodromal frailty in a community-dwelling healthy older cohort by survey of BDNF or hand grip strength classified by BMI
Mitsugu Hachisu, Masahiro Hashizume, Hisashi Kawai, Motonaga Kojima, Yoshinori Fujiwara, Shuichi Obuchi, Mari Kogo, Masayuki Ohbayashi, Noriko Koyama, Miki Takenaka, Kazushige Ihara
Published: Tuesday, September 29, 2020
Viewed: 2521
Gastrointestinal Disasters of Cetuximab in the Treatment of Metastatic Colorectal Cancer: Mechanism and its Effect on Prognosis
Junfeng Sun, Yue Wu, Haowei Jia, Xinqi Bao, Tianyu Zhu, Ruixin Li, Hongchao Zhao
Published: Monday, June 29, 2020
Viewed: 2512
Thioredoxin and aging: What have we learned from the survival studies?
Lisa Flores, Madeline Roman, Geneva Cunningham, Christie Cheng, Colton Allen, Gene Hubbard, Yidong Bai, Thomas Saunders, Yuji Ikeno
Published: Tuesday, September 29, 2020
Viewed: 2481
A model for studying cutaneous wound healing and resilience to aging: Ear punch biopsy in old mice
Warren Ladiges, Zhou Jiang, Jessie Chen, Juan Wang, Ruby Mangalindan, Lida Zhu
Published: Tuesday, September 29, 2020
Viewed: 2466
An immune stress test for resilience to aging: Pneumococcal vaccine response
Warren Ladiges, Ryan Oveson, Zhou Jiang, Michali Izhak, Kavita Sharma
Published: Tuesday, September 29, 2020
Viewed: 2445
A geropathology approach for identifying therapeutic targets to prevent pathological complications of COVID-19
Warren Ladiges, Yuji Ikeno, Liang Wang, Feng Liu
Published: Monday, June 29, 2020
Viewed: 2412
The potential of XPO1 inhibitors as a game changer in relapsed/refractory hematologic malignancies
Henan Wang, Liang Wang, Jing Yang
Published: Monday, June 29, 2020
Viewed: 2398
Anti-tumor effect of pcDNA3.1(-)/rMETase-shUCA1 hyaluronic acid-modified G5 polyamidoamine nanoparticles on gastric cancer
Chunying Xie, Zhenxing Huang, Zhaohui Huang, Yanyan Guo, Xue Zhang
Published: Monday, June 29, 2020
Viewed: 2352
The cellular senescence unification model and telomerase therapy: To treat all age-related diseases
Steve Liebich
Published: Tuesday, September 29, 2020
Viewed: 2340
Myocardial Cell Aging in the Elderly
Feng Liu, Wenxi Li
Published: Tuesday, September 29, 2020
Viewed: 2257
Eosinophilic crystalline pneumonia, an age-related lesion in mice
Jenna Klug, Jessica Snyder
Published: Thursday, December 31, 2020
Viewed: 2178
Short-term oral rapamycin prevents age-related learning impairment in mice
Warren Ladiges, Haoyi Lei, Juan Wang, Zhou Jiang
Published: Tuesday, September 29, 2020
Viewed: 2163
Immunotherapy: the blockbuster in cancer treatment
Liang Wang
Published: Tuesday, September 29, 2020
Viewed: 2145
Resilience to acute sleep deprivation is associated with attenuation of hippocampal mediated learning impairment
Warren Ladiges, Amanda Lee, Haoyi Lei, Lida Zhu, Zhou Jiang
Published: Thursday, December 31, 2020
Viewed: 2113
Sex-dependent lifespan extension of ApcMin/+ FAP mice by chronic mTOR inhibition
Manish Parihar, Sherry Dodds, Marty Javors, Randy Strong, Paul Hasty, Zelton Sharp
Published: Thursday, December 31, 2020
Viewed: 2085
2020 Reviewer Acknowledgment
Editorial Office of Aging Pathobiology and Therapeutics
Published: Thursday, December 31, 2020
Viewed: 2080
Coronary artery stenosis regression by long-term standard dose statin therapy in middle-aged and elderly patients: Report and analysis of 31 cases
Feng Liu, Zhilei Ren, Chongzhe Yang, Kaihua Huang
Published: Tuesday, September 29, 2020
Viewed: 2014
Neutrophil response to cyclophosphamide predicts resilience to age-related learning impairment
Lida Zhu, Warren Ladiges, Katie Nickel, Marianne Bjorner
Published: Thursday, December 31, 2020
Viewed: 2013
Denosumab for the treatment of osteoporosis
Shyh Poh Teo
Published: Tuesday, September 29, 2020
Viewed: 1987
Physical performance is enhanced in old mice fed a short term diet medicated with rapamycin, acarbose, and phenylbutyrate
Warren Ladiges, Megan Ellis, Zhou Jiang
Published: Monday, March 29, 2021
Viewed: 1961
miR-181c inhibits prostatic epithelial cell proliferation caused by chronic non-bacterial prostatitis through down-regulating COX-2
Xiang Ding, Xu Xu, Yuhua Huang, Jianquan Hou, Jinxing Lv
Published: Thursday, December 31, 2020
Viewed: 1953
Application and research progress of BCL2 inhibitors in elderly patients with hematologic malignancies
Liang Wang, Yufan Wang
Published: Thursday, December 31, 2020
Viewed: 1945
Spontaneous chordoma: a case report on a female UM-HET3 mouse from the SLAM study
Eleonora Duregon, Rafael de Cabo, Camila Vieira Ligo Teixeira, Dushani L. Palliyaguru, Annamaria L. Rudderow, Victoria Hoffmann, Michel Bernier, Nathan L. Price, Simonetta Camandola
Published: Thursday, December 31, 2020
Viewed: 1921
Optimal induction treatment regimens for extranodal NK/T-cell lymphoma: lessons learned, challenges, and proposals
Liang Wang, Jing Yang, Ruiying Fu, Xindi Liu, Liqiang Wei
Published: Thursday, December 31, 2020
Viewed: 1894
Castleman disease with rapidly progressive pemphigus: case report
Liang Wang, Ruiying Fu, Yingzhi He
Published: Thursday, December 31, 2020
Viewed: 1881
Progress in drug treatment of elderly chronic heart failure
Feng Liu, Siting Zhang
Published: Thursday, December 31, 2020
Viewed: 1856
Hepatic steatosis, a lesion reported in captive aged common marmosets
Sebastian Carrasco, Olga Franco-Mahecha
Published: Monday, March 29, 2021
Viewed: 1844
Recent advances in the genetic association between osteoporotic fracture and sarcopenia
Qiaocong Chen, Huiling Lou, Cheng Peng
Published: Monday, March 29, 2021
Viewed: 1814
Thioredoxin down-regulation in the cytosol in thioredoxin 2 transgenic mice did not have beneficial effects to extend lifespan in male C57BL/6 mice
Lisa Flores, Madeline Roman, Geneva Cunningham, Christie Cheng, Colton Allen, Yidong Bai, Gene Hubbard, Yuji Ikeno
Published: Thursday, December 31, 2020
Viewed: 1795
Arthritis as an adverse event of special interest post COVID-19 vaccine implementation
Shyh Poh Teo
Published: Monday, March 29, 2021
Viewed: 1788
Drug nanotargeting for treatment of neurodegeneration and aging
Joseph D'Arrigo
Published: Tuesday, June 29, 2021
Viewed: 1786
Gam-COVID-Vac (Sputnik V): a heterologous adenoviral vector-based COVID-19 vaccine
Shyh Poh Teo, Sanny Zi Lung Choo
Published: Tuesday, June 29, 2021
Viewed: 1753
Cardiac arrest in an older male patient treated with flecainide for atrial fibrillation
Tiziana Ciarambino, Rosario Bottone, Gennaro Sansone, Mauro Giordano
Published: Tuesday, June 29, 2021
Viewed: 1384
Irreversible effects of anticholinergic withdrawal in the elderly: a case report
Charisse Chehovich, Claudia Lee, Tammie Lee Demler
Published: Tuesday, June 29, 2021
Viewed: 1366
KDClassifier: A urinary proteomic spectra analysis tool based on machine learning for the classification of kidney diseases
Wanjun Zhao, Yong Zhang, Xinming Li, Yonghong Mao, Changwei Wu, Lijun Zhao, Fang Liu, Jingqiang Zhu, Jingqiu Cheng, Hao Yang, Guisen Li
Published: Thursday, September 30, 2021
Viewed: 1263
The antidiabetic drug acarbose suppresses age-related lesions in C57BL/6 mice in an organ dependent manner
Zhou Jiang, Sneh Gupta, Warren Ladiges
Published: Tuesday, June 29, 2021
Viewed: 1227
Precision aging. Human lifespan has intrinsic limits but measurable outcomes
Warren Ladiges
Published: Tuesday, June 29, 2021
Viewed: 1219
Older female relatives of Covid-19 patients have an un-satisfactory perception of emergency room performance by clinical staff
Tiziana Ciarambino, Luigia Palmiero, Rosario Bottone, Federico Schettini, Luigi Elio Adinolfi, Mauro Giordano
Published: Tuesday, June 29, 2021
Viewed: 1216
Thioredoxin – a magic bullet or a double-edged sword for mammalian aging?
Yuji Ikeno
Published: Tuesday, June 29, 2021
Viewed: 1191
A fornix infarction causing post-operative anterograde amnesia
Shyh Poh Teo
Published: Tuesday, June 29, 2021
Viewed: 1139
Chimeric antigen receptor T cell therapy in cancer: Advances and challenges
Yuanzheng Liang, Liang Wang
Published: Thursday, September 30, 2021
Viewed: 1116
Di-2-pyridylketone 4, 4-dimethyl-3-thiosemicarbazone effectively induces human colorectal carcinoma cell apoptosis via mTOR pathway
Qianqian Fu, Shengli Wang, Chuyun Zhu, Zhenlong Zhou, Xiaojuan Yu, Yong Zhang
Published: Thursday, September 30, 2021
Viewed: 1031
Progress on the study of fibroblast growth factors as novel therapeutics in post-stroke cognitive impairment
Hong Fan, Mengqi Li
Published: Thursday, September 30, 2021
Viewed: 1026
Clinical diagnosis and treatment of primary small intestinal lymphoma
Guitian Huang
Published: Thursday, September 30, 2021
Viewed: 925
Mouse modeling for anxiety disorders in older adults
Martin Darvas, Warren Ladiges, Nadia Postupna
Published: Thursday, September 30, 2021
Viewed: 823
Safety and efficacy of the Novavax vaccine—a narrative review
Shyh Poh Teo, Sanny Zi Lung Choo
Published: Friday, December 31, 2021
Viewed: 692
Association of anemia with rehabilitation outcome for subacute geriatric rehabilitation patients in a secondary hospital in malaysia
Mann Leon Chin, Christopher Chan, Huey Ee Chong, Wee Kooi Cheah
Published: Friday, December 31, 2021
Viewed: 637
The unrecognized potential of pet cats for studying aging and age-related diseases
Warren Ladiges
Published: Friday, December 31, 2021
Viewed: 499
Advances in targeting programmed cell death 1/programmed cell death-ligand 1 therapy for hematological malignancies
Liang Wang, Yuanzheng Liang, Wanying Zhao
Published: Friday, December 31, 2021
Viewed: 431
Preventive effect of rehabilitation training therapy on muscle quality in patients with stroke: A retrospective study
Xiang Lu, Dandan Feng, Wei Gao, Can Zhao, Dan Chen, Xiaojing He
Published: Friday, December 31, 2021
Viewed: 419
PathoClock and PhysioClock in mice recapitulate human multimorbidity and heterogeneous aging
Warren Ladiges, Shabnam Salimi, Christina Pettan-Brewer
Published: Friday, December 31, 2021
Viewed: 394
The aging immune system. Abstracts presented at the Masoro-Barshop conference on aging, October 13-15, 2021
Warren Ladiges
Published: Friday, December 31, 2021
Viewed: 336
Mechanisms of autophagy regulation by adiponectin
Xin Xu, Chan Rong
Published: Friday, December 31, 2021
Viewed: 276
2021 Reviewer Acknowledgment
Editorial Office of Aging Pathobiology and Therapeutics
Published: Friday, December 31, 2021
Viewed: 222