The promise of adult neurogenesis for treating and preventing chronic neurodegenerative diseases

Abstract

Chronic neurodegenerative diseases pose a significant public health challenge due to their profound impact on individual autonomy and identity. Adult neurogenesis (ANG), the ongoing generation of neurons in specific brain regions, offers promising therapeutic avenues for these diseases. Despite controversies surrounding the existence and functional relevance of ANG in humans, emerging evidence suggests individual variability in ANG induction may hold the key to understanding and addressing these conditions. We advocate for a shift in research focus towards unraveling the genetic mechanisms governing ANG and understanding its functional significance in cognition. Novel models are needed to move this concept forward. The heterogeneous domestic house cricket (Acheta domesticus) has practical advantages and potential for rapid insights into neurogenesis. This model, coupled with advanced methodologies such as immunohistochemistry and RNA sequencing, can provide a detailed understanding of ANG and its therapeutic potential. Ultimately, embracing innovative models and holistic approaches to ANG research will help unlock new strategies for treating and preventing chronic neurodegenerative diseases.

Keywords: Adult neurogenesis, neurodegenerative diseases, Acheta domesticus, immunohistochemistry, RNA sequencing