Spontaneous chordoma: a case report on a female UM-HET3  mouse from the SLAM study

Eleonora Duregon; Camila Vieira Ligo Teixeira; Dushani L. Palliyaguru; Annamaria L. Rudderow; Victoria Hoffmann; Michel Bernier; Nathan L. Price; Simonetta Camandola; Rafael de Cabo

Spontaneous chordoma: a case report on a female UM-HET3 mouse from the SLAM study

Eleonora Duregon, Camila Vieira Ligo Teixeira, Dushani L. Palliyaguru, Annamaria L. Rudderow, Victoria Hoffmann, Michel Bernier, Nathan L. Price, Simonetta Camandola, Rafael de Cabo

Abstract

A female UM-HET3 mouse from the Study of Longitudinal Aging in Mice (SLAM) was euthanized at 164 weeks of age due to hind limb weakness. Necropsy and histological analysis revealed that the most probable cause of the clinical finding was the compression of the thoracolumbar segment of the spinal cord by herniated intervertebral disks. In addition, a spontaneous chordoma was incidentally found in the coccygeal bones. Given the rarity of this type of tumor, bio-clinical annotations acquired throughout lifespan, detailed histopathological assessment, and comparative clinical-pathological correlations for this mouse are presented and discussed.

Keywords: Geropathology, geroscience, study of longitudinal aging in mice (SLAM), spontaneous neoplasm, tumor burden, chordoma

Aging Pathobiology and Therapeutics