An immune stress test for resilience to aging: Pneumococcal vaccine response | Oveson | Aging Pathobiology and Therapeutics

An immune stress test for resilience to aging: Pneumococcal vaccine response

Ryan Oveson, Zhou Jiang, Michali Izhak, Kavita Sharma, Warren Ladiges

Abstract


The idea that the degree of response to physical stress in early life can be used to measure health in later life is a novel approach to better define resilience to aging. To investigate this, middle-age (15 months) mice were stressed by vaccination with a commercial pneumococcal vaccine (Prevnar 13), and 30 days later separated into a high antibody response group and a low antibody response group using Elisa to detect IgG serum antibody levels. After 4 months, mice were evaluated for physiological performance and learning ability. The high antibody response group was able to stay on a rotating rod longer than the low antibody response group and were more quickly able to find the escape hole in a spatial navigation learning task. This observation suggests Prevnar 13 antibody response in midlife could be a useful stress test to predict healthy aging.

Keywords: Resilience to aging, immune stress test, prevnar 13 vaccine, elisa antibody titers, aging mice




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