Cartilage organoid model of osteoarthritis to study aging-related diseases

Abstract

Aging is an inevitable biological process in nature. As aging progresses, physical functions continue to decline, eventually leading to aging-related diseases. It is urgent to find effective ways to prevent and treat aging-related diseases. The use of organoids to study the development of aging-related diseases is based on the fact that they retain the physiological structure and functional characteristics of their origin, compensating for the fact that the complexity of human aging-related diseases cannot be reproduced in animals, cells, yeast, and Caenorhabditis elegans. Osteoarthritis (OA) is a common aging-related musculoskeletal disease, and chondrocyte senescence is one of the major risk factors for OA. Therefore, it is necessary to construct cartilage organoids to model OA. This brief review describes the cell source, culture environment, and intervention methods of cartilage organoids, providing insights for future drug screening and treatment of OA.

Keywords: Aging, osteoarthritis, cartilage organoid