Aging Pathobiology and Therapeutics

Aging Pathobiology and Therapeutics (APT, Online ISSN 2690-1803) is open access, peer-reviewed, interdisciplinary journal available online. The journal quarterly publishes research articles, reviews, editorials, case reports, opinions, letters, abstracts, and therapeutic drug briefs relating to research on the pathobiology of aging and age-related diseases. The journal aims to provide a platform for scientists and academicians worldwide to promote, share, and discuss various new issues and developments in different areas of the pathobiology of aging and age-related diseases. Scholars from the disciplines of geriatrics, gerontology, physiology, pathology, pharmacology, toxicology, biology, neuropsychology, psychology, nursing, epidemiology, and genetics are encouraged to contribute articles to the journal.

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Editorial Disrupted calcium homeostasis: a hidden driver of cellular aging Patricia Pantoja Newman, Brandt D. Pence Published: Tuesday, May 19, 2026

Therapeutic Brief Voluntary wheel running enhances neuronal BDNF in very old C57BL/6 mice Gina Israel, Ruby Sue Mangalindan, Warren C Ladiges, Addison Keely Published: Tuesday, May 19, 2026

Letter to Editor Low-dose radiotherapy for severe osteoarthritis refractory to conservative treatment in older adults: an underexplored option Jorge Andrés Sánchez Duque, María Camila Fernández-Gualdron, Miguel M Moreno-Capacho, Holman Duvan Ballesteros-Gomez Published: Monday, May 18, 2026

Research Article Sensory reweighting patterns and fall history in early geriatric age: implications for physiotherapy assessment Wittaya Duangnga Published: Monday, May 18, 2026

Letter to Editor Non-drug therapy for sleep disorders in the elderly: a focus on neurofeedback technology Igor Shirolapov, Alexander Zakharov Published: Tuesday, March 31, 2026

Commentary Rethinking morphine for neuropathic pain in the elderly: a neuroimmune perspective on preclinical evidence and clinical caution Shima Hashemi, Bahareh Lashtoo Aghaee, Samaneh Farrokhfar Published: Tuesday, March 31, 2026

Letter to Editor Prevalence of geriatric syndromes in patients with advanced dementia cared for by a Geriatric Home Care Unit Arís Somoano Sierra, Blanca Garmendia Prieto, Francisco Sánchez del Corral Usaola, Javier Gómez Pavón Published: Tuesday, March 31, 2026

Commentary Successful aging through integrative nutrition: a four-pillar framework for deprescribing and resilience Mehrshad Fahim Devin, Mikhail Kogan, Frame A. Leigh, Lindsey Gordon, Zeynep Celikkol, Ruhsen Ozcaglayan Published: Tuesday, March 31, 2026

Commentary From biology of reproduction to biology of aging Andrzej Bartke Published: Tuesday, March 31, 2026

Research Article Neuroprotective effect of aldehyde trapping agent, hydralazine, in a Parkinson’s disease mouse model Elizabeth Fernandez, Margaret Chia-Ying Wey, Paul Anthony Martinez, Patricia Sullivan, David Goldstein, Randy Strong Published: Tuesday, March 31, 2026

Research Article Low- vs high-load power training on muscle quality, functional performance, and multi-omic profiles in frail older adults: protocol for the FrailPow randomized controlled trial Xabier Mateos-Marañón, Iñaki Martín-Lesende, Arkaitz Larrinaga-Undabarrena, José Ramón Sánchez-Isla, Aitor Santisteban-Leguina, Iker Muñoz-Pérez, Iker Sáez, Oihana Hernández Ortiz de Urbina, Amaia Fernandez Alonso, Ana María López Rodríguez, Celia Aragón Ferrao, Irene Gómez Soto, Xabier Río Published: Tuesday, March 31, 2026

Research Article Associations between physical activity patterns and quality of life among hypertensive older adults: a logistic and principal component analysis Sarah Nadiya, Abdul Gani, Sri Andala, Meutia Zahra, Agusri Agusri, Liza Wahyuni Published: Tuesday, March 31, 2026

Review Non invasive techniques for muscle quality functional domain monitoring in older adults: a scoping review Naiara Virto, Xabier Río, Amaia Méndez-Zorrilla, Begoña García-Zapirain Published: Tuesday, March 31, 2026

Review A mechanistic narrative review of phytochemical enhancement of mitophagy in Parkinson’s disease: from PINK1/Parkin pathways to dopaminergic neuroprotection Peace Ayo Olaoluwa, Abraham Olufemi Asuku, Patrick Oluwole Abolarin, Ayodeji Johnson Ajibare, Gideon Opeyemi Ayilara Published: Tuesday, March 31, 2026

Review Accelerated biological ageing in type 2 diabetes mellitus: mechanistic, cellular, and systemic perspectives Simran C. Yadav, Shraddha V. Mahale, Sneha M. Nishad, Bhumika D. Bankar, Pooja B. Rasal Published: Tuesday, March 31, 2026