Aging Pathobiology and Therapeutics

Aging Pathobiology and Therapeutics (APT, Online ISSN 2690-1803) is open access, peer-reviewed, interdisciplinary journal available online. The journal quarterly publishes research articles, reviews, editorials, case reports, opinions, letters, abstracts, and therapeutic drug briefs relating to research on the pathobiology of aging and age-related diseases. The journal aims to provide a platform for scientists and academicians worldwide to promote, share, and discuss various new issues and developments in different areas of the pathobiology of aging and age-related diseases. Scholars from the disciplines of geriatrics, gerontology, physiology, pathology, pharmacology, toxicology, biology, neuropsychology, psychology, nursing, epidemiology, and genetics are encouraged to contribute articles to the journal.

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Research Article Cigarette exposure and aging pathways: interplay between IGF-1 suppression and TGF-β increase Titiek Hidayati, Akrom Akrom, Suny Sun Published: Sunday, September 28, 2025

Research Article Integrative bioinformatics and molecular docking unveil multi-target therapeutic mechanisms of Coptidis Rhizoma (CR) against Lewy body dementia (LBD): an in-silico approach Pranab Dev Sharma, Abdullah Al Noman Published: Friday, June 6, 2025

Review Resilience in the depths: anemones as models for aging and regeneration research Pooja B. Rasal, Gaurav N. Kasar, Durgesh S. Pagar, Aman B. Upaganlawar, Sunil K. Mahajan Published: Friday, July 18, 2025

Review Epigenetic mechanisms of the influence of aging on the development of breast cancer with the participation of retroelements Rustam Nailevich Mustafin Published: Friday, August 15, 2025

Letter to Editor Sarcopenia and intrinsic capacity in aging: implications for geriatric physiotherapy assessment and care Weslley Barbosa Sales, Melissa Silva Rocha Pereira Published: Friday, August 29, 2025

Research Article Experimental confirmation of osteoarthritis repair in vivo using epigenetic reprogramming with small molecules Javdat N. Muratkhodjaev, Saodat A. Muratkhodjaeva, Tamara U. Aripova Published: Monday, September 8, 2025

Letter to Editor Expanding the clinical implications of biomarkers and physiological indicators in geriatric institutionalization Jitendra Kumar Sinha, Shampa Ghosh, Krishna Kumar Singh Published: Thursday, September 11, 2025

Research Article Effect of continuous illumination on the ultrastructure of rat hepatocytes during ontogenesis David A. Areshidzea, Maria A Kozlova Published: Friday, September 12, 2025

Research Article Pharmacologic activation of delta133p53α reduces cellular senescence in progeria patients-derived cells Sebastien M. Joruiz, Patricia K. Dranchak, Natalia Von Muhlinen, Curtis C. Harris, Izumi Horikawa, James Inglese, Delphine Lissa Published: Tuesday, September 16, 2025

Editorial Predicting resilience to aging with physical stressors Warren Ladiges Published: Friday, September 26, 2025

Model Profile Cartilage organoid model of osteoarthritis to study aging-related diseases Guangxuan Yan, Yongxiong He, Zhiqiang Shi, Yuan Li, Kai Tao, Jun Fan, Qiankun Zhu, Heng Wang, Aitao Wang, Yongchao Li Published: Friday, June 27, 2025

Letter to Editor The role of epigenetics in cognitive aging: mechanisms, interventions, and future directions Abdullah Al Noman, Pranab Dev Sharma, Himanshu Sharma Published: Friday, June 27, 2025

Research Article Effects of structured group reminiscence in sports and non-sports environments on cognitive empowerment and optimism in older adults: a quasi-experimental study Bahador Azizi, Amin Azimkhani, Mohammad Khazaei, Saleh Moazam, Nazli Ilchizadeh, Katarzyna Dzioban Published: Friday, June 27, 2025

Research Article The estimation of the clinical status of the residents in a geriatric health service facility in Japan Toyoki Maeda Published: Friday, June 27, 2025

Commentary Biomarkers for prognostic stratification in chronic heart failure in older patients Anton R. Kiselev, Kseniya D. Dorogoykina Published: Friday, June 27, 2025