Aging Pathobiology and Therapeutics

Aging Pathobiology and Therapeutics (APT, Online ISSN 2690-1803) is open access, peer-reviewed, interdisciplinary journal available online. The journal quarterly publishes research articles, reviews, editorials, case reports, opinions, letters, abstracts, and therapeutic drug briefs relating to research on the pathobiology of aging and age-related diseases. The journal aims to provide a platform for scientists and academicians worldwide to promote, share, and discuss various new issues and developments in different areas of the pathobiology of aging and age-related diseases. Scholars from the disciplines of geriatrics, gerontology, physiology, pathology, pharmacology, toxicology, biology, neuropsychology, psychology, nursing, epidemiology, and genetics are encouraged to contribute articles to the journal.

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Review Non invasive techniques for muscle quality functional domain monitoring in older adults: a scoping review Naiara Virto, Xabier Río, Amaia Méndez-Zorrilla, Begoña García-Zapirain Published: Friday, March 27, 2026

Editorial Geropathology is a common denominator for multispecies research in geroscience, from insects to nonhuman primates Jenna Klug, Warren Ladiges Published: Thursday, March 26, 2026

Commentary Rethinking morphine for neuropathic pain in the elderly: a neuroimmune perspective on preclinical evidence and clinical caution Shima Hashemi, Bahareh Lashtoo Aghaee, Samaneh Farrokhfar Published: Thursday, March 26, 2026

Commentary From biology of reproduction to biology of aging Andrzej Bartke Published: Thursday, March 26, 2026

Research Article Associations between physical activity patterns and quality of life among hypertensive older adults: a logistic and principal component analysis Sarah Nadiya, Abdul Gani, Sri Andala, Meutia Zahra, Agusri Agusri, Liza Wahyuni Published: Wednesday, March 25, 2026

Review A mechanistic narrative review of phytochemical enhancement of mitophagy in Parkinson’s disease: from PINK1/Parkin pathways to dopaminergic neuroprotection Peace Ayo Olaoluwa, Abraham Olufemi Asuku, Patrick Oluwole Abolarin, Ayodeji Johnson Ajibare, Gideon Opeyemi Ayilara Published: Wednesday, March 25, 2026

Review Accelerated biological ageing in type 2 diabetes mellitus: mechanistic, cellular, and systemic perspectives Simran C. Yadav, Shraddha V. Mahale, Sneha M. Nishad, Bhumika D. Bankar, Pooja B. Rasal Published: Thursday, March 12, 2026

Commentary Successful aging through integrative nutrition: a four-pillar framework for deprescribing and resilience Mehrshad Fahim Devin, Mikhail Kogan, Frame A. Leigh, Lindsey Gordon, Zeynep Celikkol, Ruhsen Ozcaglayan Published: Friday, March 6, 2026

Research Article Low- vs high-load power training on muscle quality, functional performance, and multi-omic profiles in frail older adults: protocol for the FrailPow randomized controlled trial Xabier Mateos-Marañón, Iñaki Martín-Lesende, Arkaitz Larrinaga-Undabarrena, José Ramón Sánchez-Isla, Aitor Santisteban-Leguina, Iker Muñoz-Pérez, Iker Sáez, Oihana Hernández Ortiz de Urbina, Amaia Fernandez Alonso, Ana María López Rodríguez, Celia Aragón Ferrao, Irene Gómez Soto, Xabier Río Published: Saturday, February 28, 2026

Review Gut microbiome and neurodegenerative disorders: therapeutic Implications Sugato Banerjee, Ritika Ruwatia, Suparna Roy Sarkar, Subhamoy Panda Published: Thursday, November 21, 2024

Research Article Effect of dual task training versus analogy training on gait speed and balance in older adults—randomized controlled trial Yashi Shah, Reema Joshi, Chetana Tetgure Published: Saturday, December 14, 2024

Research Article Myrmecodia platytyrea tuber aqueous extract exacerbates neuroinflammation Mizaton Hazizul Hasan, Aisyah Hasyila Jahidin, Hanish Singh Jayasingh Chellammal, Ayuni Nordin, Suraya Suratman, Mohd Faiz Mustaffa Published: Monday, February 10, 2025

Research Article Exploring the neuroprotective potential of an iota-carrageenan in in vitro Parkinson's disease model: evaluation of pharmacological safety, antioxidant properties, and mitochondrial function Ricardo Basto Souza, Joana Silva, Celso Alves, Agnieszka Zofia Neugebauer, Vitória Virgínia Magalhães Soares, Raimundo Rafael de Almeida, Nágila Maria Pontes Silva Ricardo, Norma Maria Barros Benevides, Rui Pedrosa Published: Monday, February 10, 2025

Review Proteostasis in aging: mechanistic insights and therapeutic opportunities Gaurav N. Kasar, Pooja B. Rasal, Chandrashekhar D. Patil, Sunil K. Mahajan, Aman B. Upaganlawar Published: Thursday, March 6, 2025

Commentary Endotoxin-induced acute lung injury in old C57BL/6J mice is a translationally relevant geroscience model Warren Ladiges, Qianpei He, Ruby S. Mangalindan, Jenna Klug Published: Tuesday, March 18, 2025