Aging Pathobiology and Therapeutics

Aging Pathobiology and Therapeutics (APT, Online ISSN 2690-1803) is open access, peer-reviewed, interdisciplinary journal available online. The journal quarterly publishes research articles, reviews, editorials, case reports, opinions, letters, abstracts, and therapeutic drug briefs relating to research on the pathobiology of aging and age-related diseases. The journal aims to provide a platform for scientists and academicians worldwide to promote, share, and discuss various new issues and developments in different areas of the pathobiology of aging and age-related diseases. Scholars from the disciplines of geriatrics, gerontology, physiology, pathology, pharmacology, toxicology, biology, neuropsychology, psychology, nursing, epidemiology, and genetics are encouraged to contribute articles to the journal.

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Review Gut microbiome and neurodegenerative disorders: therapeutic Implications Sugato Banerjee, Ritika Ruwatia, Suparna Roy Sarkar, Subhamoy Panda Published: Thursday, November 21, 2024

Research Article Effect of dual task training versus analogy training on gait speed and balance in older adults—randomized controlled trial Yashi Shah, Reema Joshi, Chetana Tetgure Published: Saturday, December 14, 2024

Research Article Myrmecodia platytyrea tuber aqueous extract exacerbates neuroinflammation Mizaton Hazizul Hasan, Aisyah Hasyila Jahidin, Hanish Singh Jayasingh Chellammal, Ayuni Nordin, Suraya Suratman, Mohd Faiz Mustaffa Published: Monday, February 10, 2025

Research Article Exploring the neuroprotective potential of an iota-carrageenan in in vitro Parkinson's disease model: evaluation of pharmacological safety, antioxidant properties, and mitochondrial function Ricardo Basto Souza, Joana Silva, Celso Alves, Agnieszka Zofia Neugebauer, Vitória Virgínia Magalhães Soares, Raimundo Rafael de Almeida, Nágila Maria Pontes Silva Ricardo, Norma Maria Barros Benevides, Rui Pedrosa Published: Monday, February 10, 2025

Review Proteostasis in aging: mechanistic insights and therapeutic opportunities Gaurav N. Kasar, Pooja B. Rasal, Chandrashekhar D. Patil, Sunil K. Mahajan, Aman B. Upaganlawar Published: Thursday, March 6, 2025

Commentary Endotoxin-induced acute lung injury in old C57BL/6J mice is a translationally relevant geroscience model Warren Ladiges, Qianpei He, Ruby S. Mangalindan, Jenna Klug Published: Tuesday, March 18, 2025

Editorial Revisiting mitochondrial dysfunction in aging biology research Brandt D. Pence, Yufeng Zhang Published: Monday, March 24, 2025

Review Beyond hallmarks of aging – biological age and emergence of aging networks S. Michal Jazwinski, Sangkyu Kim, Jessica Fuselier Published: Monday, March 31, 2025

Letter to Editor Non-drug therapy for sleep disorders in the elderly: a focus on neurofeedback technology Igor Shirolapov, Alexander Zakharov Published: Wednesday, January 7, 2026

Research Article Dysregulation of Nrf2/ARE pathway and mitochondrial DNA damage in aging and Alzheimer’s-associated cognitive decline Polina I. Babenkova, Veronika V. Nesterova, Arina D. Tsvetkova, Anna A. Eremina, Artem P. Gureev, Vera A. Kryukova, Irina S. Sadovnikova Published: Tuesday, December 30, 2025

Commentary L-Fucose is a promising gerotherapeutic drug Warren Ladiges, Jackson Wezeman, Addison Keely Published: Tuesday, December 30, 2025

Conference Abstract Dietary approaches to geroscience intervention: 2025 Masoro-Barshop Conference on aging Adam Salmon Published: Tuesday, December 30, 2025

Case Report Untreated hip fracture as a trigger for rapid frailty progression: a case report Mayang Rizki Anggraeni, Etha Dini Widiasi, Novira Widajanti Published: Tuesday, December 30, 2025

Research Article Targeting amyloid aggregation with ethanol extracts of fermented Swietenia macrophylla: a metabolomic and molecular docking approach Agustina Lulustyaningati Nurul Aminin, Bayu Fajriansyah Al-Khairi, Mukhammad Asy’ari, Muhammad Ajmal Shah Published: Tuesday, December 30, 2025

Research Article Hecogenin, a plant-derived small molecule, as a potential therapeutic intervention for neurodegenerative disorders: insights from a zebrafish model Shametha Francis Xavier, Sanjaai K M, Deepthi Padmanabhan, Anith Kumar Rajendran, Senthilkumar Palanisamy Published: Tuesday, December 30, 2025