Aging Pathobiology and Therapeutics

Aging Pathobiology and Therapeutics (APT, Online ISSN 2690-1803) is open access, peer-reviewed, interdisciplinary journal available online. The journal quarterly publishes research articles, reviews, editorials, case reports, opinions, letters, abstracts, and therapeutic drug briefs relating to research on the pathobiology of aging and age-related diseases. The journal aims to provide a platform for scientists and academicians worldwide to promote, share, and discuss various new issues and developments in different areas of the pathobiology of aging and age-related diseases. Scholars from the disciplines of geriatrics, gerontology, physiology, pathology, pharmacology, toxicology, biology, neuropsychology, psychology, nursing, epidemiology, and genetics are encouraged to contribute articles to the journal.

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Review Inflammaging and microbiota: the intersection of aging, inflammation, and gut health Harish Rangareddy, Jessica Fryer, Achal Shetty, Hayfa Rajhi Published: Wednesday, March 19, 2025

Commentary Endotoxin-induced acute lung injury in old C57BL/6J mice is a translationally relevant geroscience model Warren Ladiges, Qianpei He, Ruby S. Mangalindan, Jenna Klug Published: Tuesday, March 18, 2025

Review Proteostasis in aging: mechanistic insights and therapeutic opportunities Gaurav N. Kasar, Pooja B. Rasal, Chandrashekhar D. Patil, Sunil K. Mahajan, Aman B. Upaganlawar Published: Thursday, March 6, 2025

Research Article Exploring the neuroprotective potential of an iota-carrageenan in in vitro Parkinson's disease model: evaluation of pharmacological safety, antioxidant properties, and mitochondrial function Ricardo Basto Souza, Joana Silva, Celso Alves, Agnieszka Zofia Neugebauer, Vitória Virgínia Magalhães Soares, Raimundo Rafael de Almeida, Nágila Maria Pontes Silva Ricardo, Norma Maria Barros Benevides, Rui Pedrosa Published: Monday, February 10, 2025

Research Article Myrmecodia platytyrea tuber aqueous extract exacerbates neuroinflammation Mizaton Hazizul Hasan, Aisyah Hasyila Jahidin, Hanish Singh Jayasingh Chellammal, Ayuni Nordin, Suraya Suratman, Mohd Faiz Mustaffa Published: Monday, February 10, 2025

Research Article From plants to potential therapeutics: exploring neuroprotective properties against Alzheimer’s disease through molecular docking and MD simulations Ashwani Kumar, Shubham Kumar, Aanchal Gupta, Chirag N. Patel, Vikas Kumar Published: Thursday, February 6, 2025

Letter to Editor Metabolic dysfunction-associated steatotic liver disease of older people Chieh Chen, Da-Ming Liao Published: Friday, August 16, 2024

Interview A natural way for a healthier lifestyle—an interview with Prof. Stephen C. Bondy Alessandro Bitto Published: Friday, August 16, 2024

Research Article Behavioral and neuropathological features of Alzheimer’s disease are attenuated in 5xFAD mice treated with intranasal GHK peptide Matthew Tucker, Gerald Yu Liao, Joo Young Park, Manuela Rosenfeld, Jackson Wezeman, Ruby Mangalindan, Dan Ratner, Martin Darvas, Warren Ladiges, Addison Keely Published: Monday, August 26, 2024

Research Article Effect of Pilates versus resistance training on physical fitness in older adults Manisha Ashish Rathi, Khushboo Muthiyan, Reema Joshi, Preeti Gazbare Published: Thursday, September 12, 2024

Editorial The promise of adult neurogenesis for treating and preventing chronic neurodegenerative diseases Warren Ladiges, Gerald Yu Liao Published: Friday, September 13, 2024

Research Article Technical development of senescence-associated β-galactosidase staining in frozen kidney tissue of Sprague Dawley rat Yuji Ikeno, Ganga Tandukar, Lisa C. Flores, Colton Allen, Yidong Bai Published: Tuesday, September 24, 2024

Research Article Two-sample mendelian randomization study: vitamin D levels and chronic kidney disease in the elderly population Ling Xiao, Kaiping Luo, Honghong Zou Published: Sunday, September 29, 2024

Interview Towards clinical translation of biomarkers and therapies targeting autolysosomal acidification dysfunction in neuroinflammation and neurodegeneration—an interview with Prof. David Rubinsztein Chih Hung Lo Published: Sunday, September 29, 2024

Interview Autophagy in neurodegeneration: recent advances, autophagosome formation, and therapeutic innovations—an interview with Prof. David Rubinsztein Aracely Garcia-Garcia Published: Thursday, December 26, 2024