Aging Pathobiology and Therapeutics

Aging Pathobiology and Therapeutics (APT, Online ISSN 2690-1803) is open access, peer-reviewed, interdisciplinary journal available online. The journal quarterly publishes research articles, reviews, editorials, case reports, opinions, letters, abstracts, and therapeutic drug briefs relating to research on the pathobiology of aging and age-related diseases. The journal aims to provide a platform for scientists and academicians worldwide to promote, share, and discuss various new issues and developments in different areas of the pathobiology of aging and age-related diseases. Scholars from the disciplines of geriatrics, gerontology, physiology, pathology, pharmacology, toxicology, biology, neuropsychology, psychology, nursing, epidemiology, and genetics are encouraged to contribute articles to the journal.

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Commentary A half-century history of aging research in San Antonio Ganga Tandukar, Lisa C. Flores, Colton Allen, Yuji Ikeno Published: Friday, December 26, 2025

Research Article The loss of methionine sulfoxide reductases significantly suppresses tumor development and exacerbates kidney pathology in male quadruple Msr knockout mice Ganga Tandukar, Lisa C. Flores, Colton Allen, Yidong Bai, Jonathan Gelfond, Yuji Ikeno, Adam Salmon Published: Friday, December 26, 2025

Review Heart rate recovery under healthy aging or age-related pathologies Anton R. Kiselev Published: Friday, December 26, 2025

Research Article Hecogenin, a plant-derived small molecule, as a potential therapeutic intervention for neurodegenerative disorders: insights from a zebrafish model Shametha Francis Xavier, Sanjaai K M, Deepthi Padmanabhan, Anith Kumar Rajendran, Senthilkumar Palanisamy Published: Friday, December 26, 2025

Research Article Targeting amyloid aggregation with ethanol extracts of fermented Swietenia macrophylla: a metabolomic and molecular docking approach Agustina Lulustyaningati Nurul Aminin, Bayu Fajriansyah Al-Khairi, Mukhammad Asy’ari, Muhammad Ajmal Shah Published: Friday, December 26, 2025

Case Report Untreated hip fracture as a trigger for rapid frailty progression: a case report Mayang Rizki Anggraeni, Etha Dini Widiasi, Novira Widajanti Published: Friday, December 26, 2025

Conference Abstract Dietary approaches to geroscience intervention: 2025 Masoro-Barshop Conference on aging Adam Salmon Published: Friday, December 5, 2025

Commentary L-Fucose is a promising gerotherapeutic drug Warren Ladiges, Jackson Wezeman, Addison Keely Published: Friday, October 31, 2025

Research Article Dysregulation of Nrf2/ARE pathway and mitochondrial DNA damage in aging and Alzheimer’s-associated cognitive decline Polina I. Babenkova, Veronika V. Nesterova, Arina D. Tsvetkova, Anna A. Eremina, Artem P. Gureev, Vera A. Kryukova, Irina S. Sadovnikova Published: Thursday, October 23, 2025

Research Article Cigarette exposure and aging pathways: interplay between IGF-1 suppression and TGF-β increase Titiek Hidayati, Akrom Akrom, Suny Sun Published: Sunday, September 28, 2025

Research Article Integrative bioinformatics and molecular docking unveil multi-target therapeutic mechanisms of Coptidis Rhizoma (CR) against Lewy body dementia (LBD): an in-silico approach Pranab Dev Sharma, Abdullah Al Noman Published: Friday, June 6, 2025

Review Resilience in the depths: anemones as models for aging and regeneration research Pooja B. Rasal, Gaurav N. Kasar, Durgesh S. Pagar, Aman B. Upaganlawar, Sunil K. Mahajan Published: Friday, July 18, 2025

Review Epigenetic mechanisms of the influence of aging on the development of breast cancer with the participation of retroelements Rustam Nailevich Mustafin Published: Friday, August 15, 2025

Letter to Editor Sarcopenia and intrinsic capacity in aging: implications for geriatric physiotherapy assessment and care Weslley Barbosa Sales, Melissa Silva Rocha Pereira Published: Friday, August 29, 2025

Research Article Experimental confirmation of osteoarthritis repair in vivo using epigenetic reprogramming with small molecules Javdat N. Muratkhodjaev, Saodat A. Muratkhodjaeva, Tamara U. Aripova Published: Monday, September 8, 2025