Aging Pathobiology and Therapeutics

Aging Pathobiology and Therapeutics (APT, Online ISSN 2690-1803) is open access, peer-reviewed, interdisciplinary journal available online. The journal quarterly publishes research articles, reviews, editorials, case reports, opinions, letters, abstracts, and therapeutic drug briefs relating to research on the pathobiology of aging and age-related diseases. The journal aims to provide a platform for scientists and academicians worldwide to promote, share, and discuss various new issues and developments in different areas of the pathobiology of aging and age-related diseases. Scholars from the disciplines of geriatrics, gerontology, physiology, pathology, pharmacology, toxicology, biology, neuropsychology, psychology, nursing, epidemiology, and genetics are encouraged to contribute articles to the journal.

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Model Profile Cartilage organoid model of osteoarthritis to study aging-related diseases Guangxuan Yan, Yongxiong He, Zhiqiang Shi, Yuan Li, Kai Tao, Jun Fan, Qiankun Zhu, Heng Wang, Aitao Wang, Yongchao Li Published: Friday, June 27, 2025

Letter to Editor The role of epigenetics in cognitive aging: mechanisms, interventions, and future directions Abdullah Al Noman, Pranab Dev Sharma, Himanshu Sharma Published: Friday, June 27, 2025

Research Article Effects of structured group reminiscence in sports and non-sports environments on cognitive empowerment and optimism in older adults: a quasi-experimental study Bahador Azizi, Amin Azimkhani, Mohammad Khazaei, Saleh Moazam, Nazli Ilchizadeh, Katarzyna Dzioban Published: Friday, June 27, 2025

Research Article The estimation of the clinical status of the residents in a geriatric health service facility in Japan Toyoki Maeda Published: Friday, June 27, 2025

Commentary Biomarkers for prognostic stratification in chronic heart failure in older patients Anton R. Kiselev, Kseniya D. Dorogoykina Published: Friday, June 27, 2025

Research Article From plants to potential therapeutics: exploring neuroprotective properties against Alzheimer’s disease through molecular docking and MD simulations Ashwani Kumar, Shubham Kumar, Aanchal Gupta, Chirag N. Patel, Vikas Kumar Published: Friday, June 27, 2025

Review Inflammaging and microbiota: the intersection of aging, inflammation, and gut health Harish Rangareddy, Jessica Fryer, Achal Shetty, Hayfa Rajhi Published: Friday, June 27, 2025

Editorial The neuropathology of aging and Alzheimer’s disease in domestic cats Warren Ladiges, Ankita Sharma Published: Friday, June 27, 2025

Research Article Integrative bioinformatics and molecular docking unveil multi-target therapeutic mechanisms of Coptidis Rhizoma (CR) against Lewy body dementia (LBD): an in-silico approach Pranab Dev Sharma, Abdullah Al Noman Published: Friday, June 6, 2025

Review Gut microbiome and neurodegenerative disorders: therapeutic Implications Sugato Banerjee, Ritika Ruwatia, Suparna Roy Sarkar, Subhamoy Panda Published: Thursday, November 21, 2024

Research Article Effect of dual task training versus analogy training on gait speed and balance in older adults—randomized controlled trial Yashi Shah, Reema Joshi, Chetana Tetgure Published: Saturday, December 14, 2024

Research Article Myrmecodia platytyrea tuber aqueous extract exacerbates neuroinflammation Mizaton Hazizul Hasan, Aisyah Hasyila Jahidin, Hanish Singh Jayasingh Chellammal, Ayuni Nordin, Suraya Suratman, Mohd Faiz Mustaffa Published: Monday, February 10, 2025

Research Article Exploring the neuroprotective potential of an iota-carrageenan in in vitro Parkinson's disease model: evaluation of pharmacological safety, antioxidant properties, and mitochondrial function Ricardo Basto Souza, Joana Silva, Celso Alves, Agnieszka Zofia Neugebauer, Vitória Virgínia Magalhães Soares, Raimundo Rafael de Almeida, Nágila Maria Pontes Silva Ricardo, Norma Maria Barros Benevides, Rui Pedrosa Published: Monday, February 10, 2025

Review Proteostasis in aging: mechanistic insights and therapeutic opportunities Gaurav N. Kasar, Pooja B. Rasal, Chandrashekhar D. Patil, Sunil K. Mahajan, Aman B. Upaganlawar Published: Thursday, March 6, 2025

Commentary Endotoxin-induced acute lung injury in old C57BL/6J mice is a translationally relevant geroscience model Warren Ladiges, Qianpei He, Ruby S. Mangalindan, Jenna Klug Published: Tuesday, March 18, 2025