Aging Pathobiology and Therapeutics

Aging Pathobiology and Therapeutics (APT, Online ISSN 2690-1803) is open access, peer-reviewed, interdisciplinary journal available online. The journal quarterly publishes research articles, reviews, editorials, case reports, opinions, letters, abstracts, and therapeutic drug briefs relating to research on the pathobiology of aging and age-related diseases. The journal aims to provide a platform for scientists and academicians worldwide to promote, share, and discuss various new issues and developments in different areas of the pathobiology of aging and age-related diseases. Scholars from the disciplines of geriatrics, gerontology, physiology, pathology, pharmacology, toxicology, biology, neuropsychology, psychology, nursing, epidemiology, and genetics are encouraged to contribute articles to the journal.

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Therapeutic Brief Voluntary wheel running enhances neuronal BDNF in very old C57BL/6 mice Gina Israel, Ruby Sue Mangalindan, Warren C Ladiges, Addison Keely Published: Tuesday, June 30, 2026

Mini Review The microgram hypothesis: a translational dosing error in Epitalon peptide research and its implications for human aging application Chang-Hun Jung Published: Tuesday, June 30, 2026

Mini Review Countering oxysterol-driven neurodegeneration: diosgenin as a privileged steroidal scaffold for novel Alzheimer’s disease therapeutics Sarvesh Sabarathinam Published: Tuesday, June 30, 2026

Letter to Editor Low-dose radiotherapy for severe osteoarthritis refractory to conservative treatment in older adults: an underexplored option Jorge Andrés Sánchez Duque, María Camila Fernández-Gualdron, Miguel M Moreno-Capacho, Holman Duvan Ballesteros-Gomez Published: Tuesday, June 30, 2026

Commentary Targeting ageing: the next frontier in drug delivery systems Rajaram Mohapatra, Pratikeswar Panda Published: Tuesday, June 30, 2026

Commentary The association of post-traumatic stress disorder with accelerated aging Anton R. Kiselev Published: Tuesday, June 30, 2026

Research Article Sensory reweighting patterns and fall history in early geriatric age: implications for physiotherapy assessment Wittaya Duangnga Published: Tuesday, June 30, 2026

Research Article Genetic drift and selective pressures shaping mitochondrial ND3 variants m.10398A>G and m.10400C>T: implications for type 2 diabetes risk in India population Jwalant Waghmare, Tejas Tajane, Mamata Chandrakar, Prafulla Ambulkar, Pranita Waghmare, Bharati Taksande Published: Tuesday, June 30, 2026

Review Senotherapeutic potential of Mediterranean diet-derived bioactives in healthy aging and frailty Sedat Arslan Published: Tuesday, June 30, 2026

Research Article Approximate prediction of life expectancy in the older people using a revised equation for estimating somatic telomere length from clinical blood data Toyoki Maeda Published: Tuesday, June 30, 2026

Review Role of miR-140-5p in vascular aging and arterial stiffening: a review of potential mechanisms Muhammad Iqhrammullah, Ayers GI Kalaij, Vindasya Almeira, Febi Septiani, Priscilla CNBR Sirait, I Made Dwi Mertha Adnyana, Keviano Bobby, Sania Zahrani, Derren DCH Rampengan Published: Tuesday, June 30, 2026

Editorial Disrupted calcium homeostasis: a hidden driver of cellular aging Patricia Pantoja Newman, Brandt D. Pence Published: Tuesday, June 30, 2026

Review mTOR signaling in aging and longevity: therapeutic opportunities Gaurav N. Kasar, Pooja B. Rasal, Aman B. Upaganlawarb, Manoj S Mahajan Published: Tuesday, June 30, 2026

Editorial Brain iron in ageing: Pixels to pathways Thomas Welton Published: Tuesday, June 30, 2026

Letter to Editor Non-drug therapy for sleep disorders in the elderly: a focus on neurofeedback technology Igor Shirolapov, Alexander Zakharov Published: Tuesday, March 31, 2026