Endotoxin-induced acute lung injury in old C57BL/6J mice is a translationally relevant geroscience model

Abstract

Abstract

Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) are clinically important inflammatory lung conditions that contribute to substantial morbidity and mortality in humans, notably in the elderly population. Direct lung infection is a common cause of ALI and can be modeled by experimental administration of lipopolysaccharide (LPS) bacterial endotoxin. Acute pulmonary pathology observations are presented using an intratracheal LPS-induced ALI experimental model in aged C57BL/6J mice. Collectively the histopathologic findings in LPS treated mice demonstrate several key characteristic features of ALI, supporting the translational relevance of this model for investigating the pathogenesis of lung injury in older adults.

Keywords: Acute lung injury, bacterial endotoxin, LPS, Aging, Mouse model, Lung pathology, C57BL/6J, Greroscience