Guest Editor: Prof. Muhammad Nabeel Ghayur University of Pikeville, Pikeville, United States. Email: nabeelghayur@yahoo.com Website: https://www.sciencedirect.com/author/6506482757/muhammad-nabeel-ghayur

Guest Editor: Prof. Pierluigi Diotaiuti Department of Human Sciences, Society and Health, University of Cassino and Southern Lazio, 03043 Cassino, Italy Email: p.diotaiuti@unicas.it Website: https://orcid.org/0000-0002-5470-3233

Alzheimer’s disease (AD) is one of the most pressing health challenges of our time, affecting millions of individuals worldwide and placing an enormous burden on families, caregivers, and healthcare systems. Despite decades of research, the exact causes and mechanisms behind Alzheimer’s remain incompletely understood, making it difficult to develop effective treatments.

This special issue of Aging Pathobiology and Therapeutics aims to bring together original research and expert reviews that shed light on the complex molecular mechanisms underlying Alzheimer’s disease pathogenesis. AD is known to arise from multiple, interrelated factors. These include genetic predispositions, abnormal protein aggregation (such as amyloid-β plaques and tau tangles), synaptic dysfunction, mitochondrial impairment, oxidative stress, neuroinflammation, and vascular contributions to cognitive decline. Beyond biology, lifestyle-related factors such as diet, exercise, sleep, and other choices also play an important role in determining risk and disease progression.

The goal of this issue is to provide readers with a comprehensive overview of current knowledge and new directions in the field. We are particularly interested in manuscripts that address:

• Pathological changes in the brain associated with AD.
• Etiological factors and disease triggers at molecular and cellular levels.
• Novel insights into protein misfolding, aggregation, and clearance pathways.
• The role of inflammation, oxidative stress, and vascular health in AD pathogenesis.
• Lifestyle determinants and modifiable risk factors, including nutrition, physical activity, and comorbid conditions.
• Potential and emerging therapeutic targets for Alzheimer’s disease.
• Mechanisms of action for existing and experimental drugs, as well as non-pharmacological interventions.

By highlighting advances across these areas, this special issue seeks to deepen our understanding of Alzheimer’s disease and open avenues for new preventive, diagnostic, and therapeutic strategies. We welcome original research articles, reviews, short communications, and perspectives that can contribute to building a more complete picture of Alzheimer’s biology and its clinical implications.

Through this effort, we hope to foster dialogue across disciplines and accelerate progress toward effective interventions that can improve outcomes for patients and families living with Alzheimer’s disease.

Manuscript Submission Information

Manuscripts should be submitted online at www.antpublisher.com through the online submission system. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, Review articles as well as Therapeutic Brief are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. APT is an international peer-reviewed open access quarterly journal published by ANT.

Please visit the Instructions for Authors page before submitting a manuscript. Considering limited grants for some researchers, Prof. Muhammad Nabeel Ghayur, Prof. Pierluigi Diotaiuti and the editorial office made the decision that Article Processing Charges will be fully exempted, which means that there are NOT any manuscript processing or publication fees for your article once accepted after standard peer-review.

Submission Deadline

May 31th, 2026

Participants

Contacts

Updated on November 03, 2023