Posted On 2022-12-16

Guest Editor: Xiang Xie, PhD

Professor, First Affiliated Hospital of Xinjiang Medical University, Urumqi, China. 



Dear Colleagues,

Aging involves changes in the complex regulatory interplay among cells, organs, and systemsm, which is characterized by functional decline in homeostatic regulation and vital cellular events. This process can be associated with the development of cardiovascular diseases. Furthermore, aging-induced biological alterations that are associated with CVDs through various aspect, such as structural, biochemical, and functional modifications; autonomic nervous system (ANS) dysregulation; epigenetic alterations; and atherosclerosis and stroke development. Aging-mediated structural and biochemical modifications coupled with gradual loss of ANS regulation, vascular stiffening, and deposition of collagen and calcium often disrupt cardiovascular system homeostasis. Therefore, the understanding of the aging-mediated changes remains promising towards effective diagnosis, discovery of new drug targets, and development of new therapies for the treatment of CVDs. We welcome original clinical, pre-clinical or basic research papers. Reviews that identify problems or challenges, present a dedicated overview or provide solutions or prospects will also be considered.

Prof. Xiang Xie
Guest Editor


Manuscript Submission Information

Manuscripts should be submitted online at through the online submission system. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, Review articles as well as Therapeutic Brief are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. APT is an international peer-reviewed open access quarterly journal published by ANT.

Please visit the Instructions for Authors page before submitting a manuscript. Considering limited grants for some researchers, Dr. Xiang Xie and the editorial office made the decision that Article Processing Charges will be fully exempted, which means that there are NOT any manuscript processing or publication fees for your article once accepted after standard peer-review.


Submission Deadline

June 30th, 2024



Andrew J. Gorton, VPGY-3, Integrated Cardiothoracic Surgery Program University of Kentucky 740 S. Limestone, Suite A301 Lexington, KY 40536.

Gohar Azhar, Department of Geriatrics, University of Arkansas for Medical Sciences, Little Rock, AR 72205 USA.

Richard Conway, Trinity College and St. James Hospital, Dublin, Ireland.

M Abdalbary, Mansoura Nephrology & Dialysis Unit, Mansoura University, Mansoura, Egypt.

Ghassan Bkaily, Department of Immunology and Cell Biology, Faculty of Medicine and Health Sciences, Université de Sherbrooke, Sherbrooke, Canada.

Ibrahim Topuz, Faculty of Health Sciences, Amasya University, Amasya, Turkey.



June Wong, Managing Editor,
Alan Zhou, Assistant Editor,


Updated on March 24, 2023

Table of Contents


Safa Alkhayyat, Zahraa Alhoori, Mohamed Abdalbary
Received: Tuesday, August 1, 2023      Published: Thursday, September 28, 2023
Patricia Harkins, Sharon Cowley, Robert Harrington, David Kane, Richard Conway
Received: Friday, August 18, 2023      Published: Thursday, September 28, 2023

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