Posted On 2022-06-27


Guest Editor: Asso. Prof. Simon Johnson


Department of Pathology, University of Washington, Seattle, Washington 98195, USA.







Mitochondrial dysfunction is linked to a range of human pathologies including heritable genetic mitochondrial diseases, complex multigenic human traits, environmental toxicities, nutrition related conditions, age-related diseases, and aging itself. Mitochondria are the organelles best known for the roles they play in production of ATP and are often thought of as simply the ‘powerhouse of the cell’. Contrary to this simplified view, mitochondria perform a wide range of critical functions including modulation of nutrient signaling pathways, maintenance of proteostasis, regulation of programmed cell death, calcium buffering, and production of reactive oxygen species and regulation of redox. Mitochondrial dyfunction is a hallmark of aging, and dysregulation of mitochondrial processes plays a major role in many aging-related diseases. The most notable examples are age-related neurodegenerative diseases such as Parkinson’s disease, where mutations in mitochondrial quality control pathways and environmental mitotoxins have been independently causally linked to disease. The precise mechanistic relationships between individual mitochondria-regulated processes and various age-related diseases, and aging, is an active area of study, with a great deal left to resolve. Given the role of mitochondrial dysfunction in human disease, strategies and agents designed to targeting mitochondria are of great interest to public health, particularly with respect to age-related diseases.


Manuscript Submission Information

Manuscripts should be submitted online at through the online submission system. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, Review articles as well as Therapeutic Brief are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. APT is an international peer-reviewed open access quarterly journal published by ANT.

Please visit the Instructions for Authors page before submitting a manuscript. Considering limited grants for some researchers, Dr. Simon Johnson and the editorial office made the decision that Article Processing Charges will be fully exempted, which means that there is NOT any manuscript processing or publication fees for your article once accepted after standard peer-review.


Submission Deadline

December 31, 2022




June Wong, Managing Editor,
Alan Zhou, Assistant Editor,


Updated on June 27, 2022

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